0001558370-23-008120 Sample Contracts

Certain information in this document has been omitted from this exhibit because it is both
Mutual Termination Agreement • May 4th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations

This Mutual Termination Agreement (this “Termination Agreement”), effective April 30, 2023 (“Termination Effective Date”), is by and between F. Hoffmann-La Roche Ltd, with an office and place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland and Hoffmann-La Roche Inc., with an office and place of business at 150 Clove Road, Suite 8, Little Falls, New Jersey 07424 U.S.A. (together referred to as “Roche”), and Blueprint Medicines Corporation, with a principal place of business at 45 Sidney Street, Cambridge, Massachusetts 02139 U.S.A. (“BPM”). Capitalized terms used and not otherwise defined in this Termination Agreement shall have the meanings set forth in the Agreement (as defined below).

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