FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENTLoan and Security Agreement • July 25th, 2016 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California
Contract Type FiledJuly 25th, 2016 Company Industry JurisdictionTHIS FOURTH AMENDMENT (this “Amendment”) to the Loan and Security Agreement, dated as of August 11, 2015, as previously amended pursuant to that certain First Amendment thereto dated as of September 28, 2015, that certain Second Amendment thereto dated as of December 31, 2015, and that Third Amendment thereto dated as of February 25, 2016 (as so amended, the “Loan Agreement”), is made by and among MAST THERAPEUTICS, INC., a Delaware corporation (“Borrower”), HERCULES CAPITAL, INC. (formerly known as Hercules Technology Growth Capital, Inc.), a Maryland corporation, as administrative agent (“Agent”), and the lender party hereto (“Lender”), and shall be effective as of July 22, 2016.