0001564590-17-003487 Sample Contracts

FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 6th, 2017 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS FIFTH AMENDMENT (this “Amendment”), dated as of March 3, 2017 and effective as of the Effective Date (as defined below), to the Loan and Security Agreement, dated as of August 11, 2015 (as amended by the Prior Amendments (as defined below), the “Loan Agreement”), is made by and among MAST THERAPEUTICS, INC., a Delaware corporation (“Borrower”), HERCULES CAPITAL, INC. (formerly known as Hercules Technology Growth Capital, Inc.), a Maryland corporation, as administrative agent (“Agent”), and the lender party hereto (“Lender”).

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SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS
Separation Agreement • March 6th, 2017 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS (hereinafter “Agreement”) is entered into by and between R. Martin Emanuele (hereinafter “Employee”) and Mast Therapeutics, Inc. (hereinafter “Mast”). Employee and Mast hereinafter are collectively referred to as “the Parties.”

TEMPORARY EMPLOYMENT AGREEMENT
Temporary Employment Agreement • March 6th, 2017 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS TEMPORARY EMPLOYMENT AGREEMENT (“Agreement”) is entered into and becomes effective as of October 31, 2016, by and between Mast Therapeutics, Inc. and all related entities, affiliates and subsidiaries (“Mast” or “Employer”) and R. Martin Emanuele (“Employee”).

SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS
Separation Agreement and General Release of Claims • March 6th, 2017 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS (hereinafter “Agreement”) is entered into by and between Gregory D. Gorgas (hereinafter “Employee”) and Mast Therapeutics, Inc. (hereinafter “Mast”). Employee and Mast hereinafter are collectively referred to as “the Parties.”

THIRD AMENDMENT TO WARRANT AGREEMENT
Warrant Agreement • March 6th, 2017 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS THIRD AMENDMENT (this “Amendment”), dated as of March 3, 2017, to the Warrant Agreement to Purchase Shares of the Common Stock of Mast Therapeutics, Inc., dated as of August 11, 2015 (as amended by the Prior Amendments (as defined below), the “Warrant Agreement”), is made by and between MAST THERAPEUTICS, INC., a Delaware corporation (the “Company”), and HERCULES TECHNOLOGY III, L.P., a Delaware limited partnership (the “Warrantholder”).

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