0001564590-17-015414 Sample Contracts

May 8, 2017 To: Xenon Pharmaceuticals Inc. Attention: Simon Pimstone, President and Chief Executive Officer Burnaby, BC V5G 4W8 Xenon Pharmaceuticals Inc. Attention: General Counsel and Corporate Secretary Burnaby, BC V5G 4W8

Letter Agreement • August 3rd, 2017 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations

• Contract Type
  Letter Agreement
• Filed
  August 3rd, 2017
• Company
  Xenon Pharmaceuticals Inc.
• Industry
  Pharmaceutical preparations

Re:Collaborative Research and License Agreement between Xenon Pharmaceuticals Inc. (“Xenon”) and Genentech, Inc. (“GNE”) together with F. Hoffmann-La-Roche Ltd (“Roche”) (GNE and Roche, collectively, “Genentech”), made as of December 22, 2011, as amended (the “Agreement”)

ASSET PURCHASE AGREEMENT by and among

Asset Purchase Agreement • August 3rd, 2017 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • Delaware

• Contract Type
  Asset Purchase Agreement
• Filed
  August 3rd, 2017
• Company
  Xenon Pharmaceuticals Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

THIS ASSET PURCHASE AGREEMENT (“Agreement”) is made as of April 25, 2017 (the “Effective Date”), by and among, 1ST Order Pharmaceuticals, Inc., a Delaware Corporation (“Seller”) and Xenon Pharmaceuticals Inc., a corporation continued under the federal laws of Canada (“Acquiror”).