0001564590-18-020479 Sample Contracts

FIRST AMENDMENT TO LEASE

Lease • August 8th, 2018 • Proteostasis Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

• Contract Type
  Lease
• Filed
  August 8th, 2018
• Company
  Proteostasis Therapeutics, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Massachusetts

This FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of April 13, 2018 (the “Effective Date”) by and between ICE BOX, LLC, a Massachusetts limited liability company (“Landlord”) and PROTEOSTASIS THERAPEUTICS, INC., a Delaware corporation, with an address of 80 Guest Street, 5th Floor, Brighton, MA 02135 (“Tenant”).

FOURTH AMENDMENT TO LEASE

Lease Agreement • August 8th, 2018 • Proteostasis Therapeutics, Inc. • Pharmaceutical preparations

• Contract Type
  Lease Agreement
• Filed
  August 8th, 2018
• Company
  Proteostasis Therapeutics, Inc.
• Industry
  Pharmaceutical preparations

THIS FOURTH AMENDMENT TO LEASE (this "Fourth Amendment") is made as of April 13, 2018, by and between ARE-TECH SQUARE, LLC, a Delaware limited liability company ("Landlord"), and PROTEOSTASIS THERAPEUTICS, INC., a Delaware corporation ("Tenant").

CONSULTING AGREEMENT

Consulting Agreement • August 8th, 2018 • Proteostasis Therapeutics, Inc. • Pharmaceutical preparations

• Contract Type
  Consulting Agreement
• Filed
  August 8th, 2018
• Company
  Proteostasis Therapeutics, Inc.
• Industry
  Pharmaceutical preparations

This Consulting Agreement (the “Agreement”) is made effective as of May 7, 2018 (the “Effective Date”), by and between Proteostasis Therapeutics, Inc. a Delaware corporation, with its principal place of business being 80 Guest St, Boston, MA 02135 (the “Company”) and Danforth Advisors, LLC, a Massachusetts limited liability corporation, with its principal place of business being 91 Middle Road, Southborough, MA 01772 (“Danforth”). The Company and Danforth are herein sometimes referred to individually as a “Party” and collectively as the “Parties.”

Amendment No. 6 to Collaboration and License Agreement

Collaboration and License Agreement • August 8th, 2018 • Proteostasis Therapeutics, Inc. • Pharmaceutical preparations

• Contract Type
  Collaboration and License Agreement
• Filed
  August 8th, 2018
• Company
  Proteostasis Therapeutics, Inc.
• Industry
  Pharmaceutical preparations

This Amendment No. 6 to Collaboration and License Agreement (this “Amendment No. 6”) is made and effective as of April 23, 2018 by and between Proteostasis Therapeutics, Inc., a corporation existing under the laws of the State of Delaware, having a place of business at 200 Technology Square, 4th Floor, Cambridge, MA 02139 (“PTI”) and Astellas Pharma Inc., a Japanese corporation having its principal place of business at 5-1 Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo 103-8411, Japan (“Astellas”). Each of Astellas and PTI is sometimes referred to individually herein as a “Party” and collectively as the “Parties”.