0001564590-18-027742 Sample Contracts

FIRST SUPPLEMENTAL INDENTURE
First Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of October 23, 2017, among Horizon Pharma Tepro, Inc., a Delaware corporation (the “Guaranteeing Entity”) an indirect subsidiary of Horizon Pharma, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

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SECOND SUPPLEMENTAL INDENTURE
Second Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

SECOND SUPPLEMENTAL INDENTURE (this “Second Supplemental Indenture”), dated as of May 10, 2016, between Horizon Pharma Rheumatology LLC (the “Guaranteeing Entity”), a parent or subsidiary of Horizon Pharma, Inc. (or its permitted successor), a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

FIFTH SUPPLEMENTAL INDENTURE
Fifth Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

FIFTH SUPPLEMENTAL INDENTURE (this “Fifth Supplemental Indenture”), dated as of October 19, 2018, among Horizon Pharma Services LLC, a Delaware limited liability company (the “Guaranteeing Entity”) and an indirect subsidiary of Horizon Pharma, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

SIXTH SUPPLEMENTAL INDENTURE
Sixth Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

SIXTH SUPPLEMENTAL INDENTURE (this “Sixth Supplemental Indenture”), dated as of October 31, 2018, between Horizon Pharma USA, Inc., a Delaware corporation (the “New Issuer”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

SECOND SUPPLEMENTAL INDENTURE
Second Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

SECOND SUPPLEMENTAL INDENTURE (this “Second Supplemental Indenture”), dated as of October 19, 2018, among Horizon Pharma Services LLC, a Delaware limited liability company (the “Guaranteeing Entity”) and an indirect subsidiary of Horizon Pharma, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

THIRD SUPPLEMENTAL INDENTURE
Third Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

THIRD SUPPLEMENTAL INDENTURE (this “Third Supplemental Indenture”), dated as of October 25, 2016, among Raptor Pharmaceutical Corp., a Delaware corporation, Raptor Pharmaceuticals Inc., a Delaware corporation (collectively, the “Guaranteeing Entities”), each a parent or subsidiary of Horizon Pharma, Inc. (or its permitted successor), a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

FOURTH SUPPLEMENTAL INDENTURE
Fourth Supplemental Indenture • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New York

FOURTH SUPPLEMENTAL INDENTURE (this “Fourth Supplemental Indenture”), dated as of October 23, 2017, among Horizon Pharma Tepro, Inc., a Delaware corporation (the “Guaranteeing Entity”) an indirect subsidiary of Horizon Pharma, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

CONFIDENTIAL SETTLEMENT AND LICENSE AGREEMENT
Settlement Agreement • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations • New Jersey

This Confidential Settlement And License Agreement (the “Settlement Agreement”) is entered into by and among HORIZON THERAPEUTICS, LLC, a corporation organized and existing under the laws of the State of Delaware with a principal place of business at 150 S. Saunders Road, Lake Forest, Illinois, 60045 (“Plaintiff”) and PAR PHARMACEUTICAL, INC. (“Par”), a corporation organized and existing under the laws of New York with a principal place of business at One Ram Ridge Road, Chestnut Ridge, NY 10977 (each individually a “Party”, collectively, the “Parties”), and made effective as of the date upon final execution of the Settlement Agreement by an authorized representative of each Party (the “Effective Date”).

AMENDMENT NO. 1 TO AMENDED AND RESTATED LICENSE AGREEMENT
License Agreement • November 7th, 2018 • Horizon Pharma PLC • Pharmaceutical preparations

This Amendment No. 1 to the Amended and Restated License Agreement, (the “Amendment”) is entered into as of September 11, 2018 (the “Amendment Effective Date”), by and between:

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