0001564590-19-004084 Sample Contracts

AMENDMENT NO: 2
The Contract Manufacturing Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations • New York

This Amendment No: 2 to the Contract Manufacturing Agreement (“Amendment 2”) is made effective as of November 17, 2016 (“Amendment 2 Effective Date”) by and between

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AMENDMENT NO: 1
The Contract Manufacturing Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations • New York

This Amendment No: 1 to the Contract Manufacturing Agreement (“Amendment 1”) is made effective as of September 19, 2016 (“Amendment 1 Effective Date”) by and between

AMENDMENT NO: 4
The Contract Manufacturing Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations • New York

This Amendment No: 4 to the Contract Manufacturing Agreement (“Amendment 4”) is made effective as of June 15, 2018 (“Amendment 4 Effective Date”) by and between

AMENDMENT NO: 3.1
The Contract Manufacturing Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations • New York

This Amendment No: 3.1 to the Contract Manufacturing Agreement (“Amendment 3.1”) is made effective as of December 22, 2017 (“Amendment 3.1 Effective Date”) by and between

November 2, 2018 Elisabeth A. Sandoval, M.B.A. VIA EMAIL AND DOCUSIGN
Alder Biopharmaceuticals Inc • February 25th, 2019 • Pharmaceutical preparations • Washington

As you know, you have informed Alder BioPharmaceuticals, Inc. (the “Company”) of your desire to resign your employment, and we have been discussing the terms of your resignation. This letter sets forth the terms of the transition agreement (the “Agreement”) that the Company is offering to you to aid in your employment transition.

Re: Amendment to Offer of Employment At Alder BioPharmaceuticals, Inc. (the “Company” or “Alder”) dated December 4, 2018
Alder Biopharmaceuticals Inc • February 25th, 2019 • Pharmaceutical preparations

You and Alder entered into an offer letter agreement dated December 4, 2018 (the “Original Letter Agreement”) whereby you agreed to certain terms of employment as described in that Original Letter Agreement. For good and valuable consideration, the sufficiency of which is hereby acknowledged, you and the Company hereby agree to amend the Original Letter Agreement as described in this letter amendment (the “Amendment”).

Contract
Quality Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations

[***] = Certain confidential information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

Contract
Contract Manufacturing Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations • New York

[***] = Certain confidential information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

AMENDMENT NO. 5 TO THE CONTRACT MANUFACTURING AGREEMENT (in respect of the completion of the manufacturing relationship)
The Contract Manufacturing Agreement • February 25th, 2019 • Alder Biopharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 5 to the Contract Manufacturing Agreement (“Amendment 5”) is made effective as of January 1, 2019 (“Amendment 5 Effective Date”) by and between:

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