0001564590-19-004667 Sample Contracts

THIRD SUPPLEMENTAL INDENTURE
Third Supplemental Indenture • February 27th, 2019 • Horizon Pharma PLC • Pharmaceutical preparations • New York

THIRD SUPPLEMENTAL INDENTURE (this “Third Supplemental Indenture”), dated as of November 15, 2018, among Horizon Medicines LLC, a Delaware limited liability company (the “Guaranteeing Entity”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

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AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND GEOFF CURTIS
Executive • February 27th, 2019 • Horizon Pharma PLC • Pharmaceutical preparations • Illinois

This Amended and Restated Executive Employment Agreement (hereinafter referred to as the “Agreement”), is entered into by and between Horizon Pharma, Inc., a Delaware corporation, and its wholly owned subsidiary, Horizon Pharma USA, Inc., a Delaware corporation, each having a principal place of business at 150 S. Saunders Road, Lake Forest, IL 60045, (hereinafter referred to together as the “Company”) and Geoff Curtis (hereinafter referred as to the “Executive”). The terms of this Agreement shall be effective commencing August 1, 2018 (the “Effective Date”).

SEVENTH SUPPLEMENTAL INDENTURE
Seventh Supplemental Indenture • February 27th, 2019 • Horizon Pharma PLC • Pharmaceutical preparations • New York

SEVENTH SUPPLEMENTAL INDENTURE (this “Seventh Supplemental Indenture”), dated as of November 15, 2018, among Horizon Medicines LLC, a Delaware limited liability company (the “Guaranteeing Entity”) and an indirect subsidiary of Horizon Pharma USA, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

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