0001564590-19-012913 Sample Contracts

Re: Amendment to License and Collaboration Agreement
Alkermes Plc. • April 25th, 2019 • Pharmaceutical preparations

We refer to the License and Collaboration Agreement dated 27 November 2017 between Alkermes Pharma Ireland Limited (“Alkermes”) and Biogen Swiss Manufacturing GmBH (“Biogen”) (the “License”). This letter is supplemental to the License and amends Section 5.1.2 thereto as set out below.

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