0001564590-19-028087 Sample Contracts

AMENDMENT NO. 8 TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • August 2nd, 2019 • Ultragenyx Pharmaceutical Inc. • Pharmaceutical preparations

This Amendment No. 8 to the Collaboration and License Agreement (“Amendment”) is made and entered into by and between Kyowa Kirin Co., Ltd. (formerly, Kyowa Hakko Kirin Co., Ltd.), a company organized and existing under the laws of Japan, with an address at 1-9-2 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan (“KHK”) and Ultragenyx Pharmaceutical Inc., a company organized and existing under the laws of the State of Delaware, with an address at 60 Leveroni Court, Novato, California 94949, USA (“UGNX”).

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AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • August 2nd, 2019 • Ultragenyx Pharmaceutical Inc. • Pharmaceutical preparations • New York

This AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT (“Agreement”) is entered into as of June 3, 2019 (“A&R Effective Date”) by and between Ultragenyx Pharmaceutical Inc., a corporation organized under the laws of the State of Delaware, with offices at 60 Leveroni Court, Novato, CA 94949 (“Dimension”), and Bayer HealthCare LLC, a limited liability company organized under the laws of the State of Delaware, with offices at 455 Mission Bay Blvd South, San Francisco, CA 94158 (“Bayer”). Dimension and Bayer are hereinafter referred to individually as a “Party” and collectively as the “Parties.”

ADDENDUM 6 TO LEASE DATED JULY 1, 2011 BY AND BETWEEN ULTRAGENYX PHARMACEUTICAL, INC. AS LESSEE AND CONDIOTTI ENTERPRISES, INC. AS LESSOR
Ultragenyx Pharmaceutical Inc. • August 2nd, 2019 • Pharmaceutical preparations

On or about July 1, 2011 Lessor and Lessee entered into a lease and Addendum 1 for approximately 19,916 square feet, comprising the entire second floor of the Premises located at 60 Leveroni Court, Novato, California. Subsequent to the execution of that Lease, the parties have executed Addenda two through five (together, the “Lease”), which, in addition to such other terms and conditions agreed to facilitate operation of the Lease and the subject changes, have extended the term of the Lease to 4/30/19 and expanded the space to include all of the Premises at 60 Leveroni Court (approximately 43,517 sf) and all of the Premises at 52 Leveroni Court (approximately 20,343 sf) and the first floor of the Premises located at 68 Leveroni Court (approximately 10,408 sf), bringing the total square footage subject to the Lease and Addenda to approximately 74,268 square feet.

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