0001564590-19-040428 Sample Contracts

SECOND AMENDMENT TO LICENSE AGREEMENT
License Agreement • November 5th, 2019 • Synthorx, Inc. • Pharmaceutical preparations

This is an Amendment, dated as of August 5, 2019 (this “Second Amendment”), to the License Agreement dated July 31, 2014, as amended on September 10, 2018 (collectively, the “Agreement”), by and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation (“TSRI”), and SYNTHORX, INC., a Delaware corporation (“Licensee”).

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FIFTH AMENDMENT to RESEARCH FUNDING AND OPTION AGREEMENT
Research Funding and Option Agreement • November 5th, 2019 • Synthorx, Inc. • Pharmaceutical preparations

This Fifth Amendment (“Fifth Amendment”), entered into and made effective as of the last dated signature below (“Fifth Amendment Effective Date”), is made to RESEARCH FUNDING AND OPTION AGREEMENT dated July 31st, 2014, as amended on September 25, 2015, September 9, 2016, October 16, 2017, and August 16, 2018 (collectively, the “Agreement”) by and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation (“TSRI”), and SYNTHORX, INC., a Delaware corporation (“Sponsor”). Capitalized terms used but not defined herein shall have the same meanings set forth in the Agreement.

SUB-SUBLEASE (San Diego, California)
Sub-Sublease • November 5th, 2019 • Synthorx, Inc. • Pharmaceutical preparations • California

This Sub-Sublease (this “Sub-Sublease”) is entered into as of August 30, 2019 (the “Effective Date”), by and between Avelas Biosciences, Inc., a Delaware corporation (“Sub-Sublandlord”), and Synthorx, Inc., a Delaware corporation (“Sub-Subtenant”). Sub-Sublandlord and Sub-Subtenant may each be referred to herein as a “Party”, and collectively, the “Parties”.

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