0001564590-20-006575 Sample Contracts

License Agreement by and among a Swiss corporation; Hoffmann-La Roche Inc. a New Jersey corporation and River Vision LLC, a Delaware limited liability company
License Agreement • February 26th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations

RIVER VISION LLC, a limited liability company organized and existing under the laws of Delaware, with its principal office at One Rockefeller Plaza, New York NY, 10020, U.S.A. (“River Vision”).

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January 23, 2020 Shao Lee Lin, MD PhD
Employment Agreement • February 26th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations
AMENDMENT TO THE SUPPLY AGREEMENT BETWEEN CREALTA Pharmaceuticals LLC AND NOF CORPORATION
Supply Agreement • February 26th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations

THIS AMENDMENT (“Amendment”) is entered into effective this 30 November, 2018, (“Effective Date”) by and among Horizon Pharma Rheumatology LLC (formerly known as CREALTA Pharmaceuticals LLC), an Delaware company, with its principal place of business located at 150 South Saunders Road, Lake Forest, IL 60045, USA (“Horizon US”), Horizon Pharma Ireland Limited, an Irish company, with its principal place of business located at Connaught House, 1st Floor, 1 Burlington Road, Dublin D04 C5Y6, Ireland (“Horizon Ireland”) and NOF CORPORATION, a Japanese Corporation with its principal place of business located at 20-3, Ebisu 4-chome, Shibuya-ku, Tokyo 150-6019 Japan (“NOF”).

Amendment No. 2 to Commercial Supply Agreement BETWEEN CAMBREX PROFARMACO MILANO, and HORIZON PHARMA IRELAND LIMITED
Commercial Supply Agreement • February 26th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations

This Amendment No. 2 (“Amendment No. 2”) is made by and between Cambrex Profarmaco Milano Srl, Via E. Curiel, 34, 20067 Paullo (MI), Italy (“Cambrex”) and Horizon Pharma Ireland Limited with its registered office at Connaught House, 1st Floor, 1 Burlington Road, Dublin 4, Ireland (“Horizon”).

AMENDMENT NO. 2 TO COMMERCIAL SUPPLY AGREEMENT
Commercial Supply Agreement • February 26th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations

This Amendment No. 2 (the “Second Amendment”) to the Commercial Supply Agreement by and between Horizon Pharma Ireland Limited (“Customer”) and AGC Biologics A/S, formerly known as CMC Biologics A/S (“AGC”) is dated as of December 18, 2019 (the “Second Amendment Effective Date”).

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