0001564590-20-007353 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • February 27th, 2020 • Orchard Therapeutics PLC • Biological products, (no disgnostic substances) • Massachusetts

This Employment Agreement (“Agreement”) is made by and between Orchard Therapeutics plc (the “Parent”), Orchard Therapeutics North America, a California corporation (the “U.S. Subsidiary”), and Frank Thomas (the “Executive”), and is effective upon the date it is fully executed (the “Effective Date”). The Parent, the U.S. Subsidiary, and their respective subsidiaries and other affiliates are collectively referred to herein as the “Company,” and the duties of the Company set forth in this Agreement may be discharged by any entity within that definition. Except with respect to the Equity Documents and subject to Section 10 below, this Agreement fully supersedes and replaces in all respects all prior agreements between the parties regarding the subject matter herein, including without limitation (i) the offer letter between Orchard Therapeutics Limited (a subsidiary of the Parent) and the Executive dated January 12, 2018 and (ii) any other offer letter, employment agreement or severance ag

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INCENTIVE SHARE OPTION AGREEMENT UNDER THE ORCHARD THERAPEUTICS PLC 2018 SHARE OPTION AND INCENTIVE PLAN
Non-Qualified Share Option Agreement • February 27th, 2020 • Orchard Therapeutics PLC • Biological products, (no disgnostic substances)

Pursuant to the Orchard Therapeutics plc 2018 Share Option and Incentive Plan as amended through the date hereof (the “Plan”), Orchard Therapeutics plc (the “Company”) hereby grants to the Optionee named above an option (the “Share Option”) to purchase on or prior to the Expiration Date specified above all or part of the number of Shares specified above at the Option Exercise Price per Share specified above subject to the terms and conditions set forth herein and in the Plan.

CONTRACT OF EMPLOYMENT
Orchard Therapeutics PLC • February 27th, 2020 • Biological products, (no disgnostic substances) • England and Wales

This Contract of Employment (“the Contract”) includes the particulars of employment required under Section 1 of the Employment Rights Act 1996 (as amended).

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