0001564590-20-007398 Sample Contracts

LOAN AGREEMENT Dated as of November 4, 2019
Loan Agreement • February 27th, 2020 • Epizyme, Inc. • Pharmaceutical preparations • New York

THIS LOAN AGREEMENT (this “Agreement”), dated as of November 4, 2019 (the “Execution Date”) by and among EPIZYME, INC., a Delaware corporation (as “Borrower”), BIOPHARMA CREDIT PLC, a public limited company incorporated under the laws of England and Wales (as the “Collateral Agent” and a “Lender”) and BIOPHARMA CREDIT INVESTMENTS V (MASTER) LP, a Cayman Islands exempted limited partnership (as a “Lender”), provides the terms on which each Lender shall make, and Borrower shall repay, the Credit Extensions (as hereinafter defined). The parties hereto agree as follows:

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GUARANTY AND SECURITY AGREEMENT Dated as of November 18, 2019 by EPIZYME, INC. (as Borrower), and
Guaranty and Security Agreement • February 27th, 2020 • Epizyme, Inc. • Pharmaceutical preparations • New York

WHEREAS, pursuant to the Loan Agreement dated as of November 4, 2019 (as the same may be amended, restated, amended and restated, supplemented or otherwise modified from time to time, the “Loan Agreement”) by and among Borrower, the Collateral Agent and the other parties thereto, Lenders agrees to make extensions of credit to Borrower upon the terms and subject to the conditions set forth therein;

Contract
Warrant Agreement • February 27th, 2020 • Epizyme, Inc. • Pharmaceutical preparations • Delaware

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AND PURSUANT TO THE PROVISIONS OF ARTICLE 5 BELOW, MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAW OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS EXEMPT FROM REGISTRATION.

Purchase Agreement by and between Epizyme, Inc. and RPI Finance Trust
Purchase Agreement • February 27th, 2020 • Epizyme, Inc. • Pharmaceutical preparations • New York

THIS PURCHASE AGREEMENT (the “Agreement”) is made as of November 4, 2019, by and between Epizyme, Inc., a Delaware corporation (the “Company”), and RPI Finance Trust, a Delaware statutory trust (the “Investor”).

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