0001564590-20-014536 Sample Contracts

SECOND AMENDMENT TO THE COLLABORATION AGREEMENT
The Collaboration Agreement • March 31st, 2020 • BioNTech SE • Biological products, (no disgnostic substances)

This SECOND AMENDMENT (the “Second Amendment”) is made and entered into, effective as of December 6, 2019 (the “Second Amendment Effective Date”), by and between BioNTech RNA Pharmaceuticals GmbH, a limited liability company organized under the laws of Germany (“RNP”) and BioNTech SE, a European stock corporation (“BNT”) (RNP and BNT collectively, “BioNTech”), and Genentech, Inc., a corporation organized under the laws of the State of Delaware (“GNE”) and F. Hoffmann-La Roche Ltd, a corporation organized under the laws of Switzerland (“Roche”) (GNE and Roche, collectively, “Genentech”).

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FIRST AMENDMENT TO THE COLLABORATION AGREEMENT
The Collaboration Agreement • March 31st, 2020 • BioNTech SE • Biological products, (no disgnostic substances)

is made and entered into, effective as of June 1, 2018 ("Amendment Effective Date"), by and between BioNTech RNA Pharmaceuticals GmbH, a limited liability company organized under the laws of Germany ("RNP") and BioNTech AG, a stock corporation organized under the laws of Germany ("BNT") (RNP and BNT collectively, "BioNTech"), and Genentech, Inc., a corporation organized under the laws of the State of Delaware ("GNE") and F. Hoffmann-La Roche Ltd, a corporation organized under the laws of Switzerland ("Roche") (GNE and Roche, collectively, "Genentech"). BioNTech and Genentech are sometimes referred to herein individually as a "Party" and collectively as the "Parties ."

COMPANY IF PUBLICLY DISCLOSED
BioNTech SE • March 31st, 2020 • Biological products, (no disgnostic substances)
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