0001564590-20-021536 Sample Contracts

FIRST SUPPLEMENTAL INDENTURE
Supplemental Indenture • May 6th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of November 19, 2019, between HZNP FINANCE LIMITED (the “Guaranteeing Entity”), a subsidiary of Horizon Therapeutics USA, Inc. (formerly known as Horizon Pharma USA, Inc.), a Delaware corporation (the “Issuer”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

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SECOND SUPPLEMENTAL INDENTURE
Supplemental Indenture • May 6th, 2020 • Horizon Therapeutics Public LTD Co • Pharmaceutical preparations • New York

SECOND SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of April 23, 2020, between HORIZON PROPERTIES HOLDING LLC and CURZION PHARMACEUTICALS, INC. (each, a “Guaranteeing Entity”), each a subsidiary of Horizon Therapeutics USA, Inc. (formerly known as Horizon Pharma USA, Inc.), a Delaware corporation (the “Issuer”), and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”).

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