0001567619-16-001797 Sample Contracts

PATHEON N.V. SHAREHOLDERS’ AGREEMENT Dated as of [•]
Shareholders’ Agreement • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations • Delaware

This SHAREHOLDERS’ AGREEMENT (this “Agreement”), dated as of [•], 2016, is made and entered into by and among Patheon N.V., a Dutch public limited liability company (the “Company”), JLL Patheon Co-Investment Fund, L.P., a Cayman Islands exempted limited partnership (“JLL”), Koninklijke DSM N.V., a Dutch public limited company (“DSM”), and JLL/Delta Patheon Holdings, L.P., a Cayman Islands exempted limited partnership (the “Partnership”) (JLL, DSM, the Partnership and any other shareholder of the Company who may hereafter become a signatory to this Agreement each being referred to herein as a “Shareholder” and collectively being referred to herein as the “Shareholders”).

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EMPLOYMENT AGREEMENT
Employment Agreement • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations • Massachusetts

This Employment Agreement (the “Agreement”) is made as of no later than November 1, 2014 (the “Effective Date”), between Patheon Pharmaceutical Services Inc. (the “Company”) and Eric M. Sherbet (the “Executive”).

SEVENTH SUPPLEMENTAL INDENTURE
Seventh Supplemental Indenture • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations • New York

Supplemental Indenture (this “Supplemental Indenture”), dated as of January 14, 2016, among Patheon Holdings Cooperatief U.A. (the “Parent Guarantor”), the indirect parent of DPx Holdings B.V. (formerly known as JLL/Delta Dutch Newco B.V.), a private limited liability company organized under the laws of the Netherlands, as Issuer (under the Indenture referred to below), the Issuer and Wells Fargo Bank, National Association, as trustee (under the Indenture referred to below) (the “Trustee”).

February 24, 2014 PRIVATE AND CONFIDENTIAL Lukas Utiger RE: Assignment of and Amendment to Employment Contract Dear Lukas:
Private and Confidential • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations

Further to our discussions, this letter (the “Letter”), effective as of January 1, 2015 (the “Amendment Effective Date”), confirms that your employment is being transferred to Patheon Pharmaceutical Services Inc. (the “Company”) and, accordingly, your employment agreement, dated July 24,2013 (“Employment Agreement”), has been assigned by DSM Pharmaceutical Products Inc. to the Company. Once signed, this Letter will serve as an amendment to the Employment Agreement between you and the Company. Any terms used in this letter that are not defined herein have the definition ascribed to them in the Employment Agreement.

AMENDMENT NO. 3 TO CREDIT AGREEMENT
Credit Agreement • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations • New York

This Amendment No. 3 (this “Amendment”) is dated as of January 8, 2016, by and among DPX HOLDINGS B.V., a private company with limited liability incorporated under the laws of the Netherlands (the “Parent Borrower”), the Lenders party hereto, and UBS AG, STAMFORD BRANCH, as administrative agent for the Lenders (the “Administrative Agent”).

BIOLOGICS AGREEMENT
Biologics Agreement • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations

This BIOLOGICS AGREEMENT, dated as of January 29, 2016 (this “Agreement”), is made by and among Patheon Holdings Coöperatief U.A., a Dutch cooperative with excluded liability (the “Company”), JLL Patheon Co-Investment Fund, L.P., a Cayman Islands exempted limited partnership (“JLL”), Koninklijke DSM N.V., a corporation organized under the laws of The Netherlands (“DSM”), and JLL/DSM Patheon Holdings, L.P., a Cayman Islands exempted limited partnership (the “Partnership”).

FIRST SUPPLEMENTAL INDENTURE
First Supplemental Indenture • February 5th, 2016 • Patheon Holdings Cooperatief U.A. • Pharmaceutical preparations • New York

First Supplemental Indenture (this “Supplemental Indenture”), dated as of January 14, 2016, among Patheon Holdings Cooperatief U.A. (the “Parent Guarantor”), the indirect parent of JLL/Delta Dutch Pledgeco B.V., a private limited liability company organized under the laws of the Netherlands (the “Issuer”), the Issuer and The Bank of New York Mellon, as trustee (under the Indenture referred to below) (the “Trustee”).

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