0001609351-19-000042 Sample Contracts

FIRST AMENDMENT TO LEASE
Spark Therapeutics, Inc. • February 28th, 2019 • Biological products, (no disgnostic substances)

THIS FIRST AMENDMENT TO LEASE (“Amendment”) is made and entered into as of October 1, 2018, by and between BRANDYWINE 3025 MARKET, LP, a Pennsylvania limited partnership (“Landlord”), and SPARK THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

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LICENSE AGREEMENT AMENDMENT
License Agreement • February 28th, 2019 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances)

This Amendment (the "Amendment"), with an effective date of November 23, 2015 (the "Effective Date") serves as a modification to the November 23, 2015 License Agreement made by and between Spark Therapeutics, Inc., a Delaware corporation having a principle place of business at 3737 Market Street, Suite 1300 Philadelphia, Pennsylvania, 19104 ("SPARK"), and The Children's Hospital of Philadelphia®, a non-profit entity organized and existing under the laws of Pennsylvania and having a principal place of business at 34th and Civic Center Boulevard, Philadelphia, PA 19104 ("CHOP") (the "[**] Agreement"). Each of SPARK and CHOP may be referred to herein individually as a "Party" and together as the "Parties".

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