0001615774-16-004680 Sample Contracts

March 24, 2016 Kevin G. Sarney c/o Enumeral Biomedical Holdings, Inc.
Enumeral Biomedical Holdings, Inc. • March 30th, 2016 • Pharmaceutical preparations
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COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENT BY AND BETWEEN ENUMERAL BIOMEDICAL HOLDINGS, INC. and THE UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER January 11, 2016
Confidential • March 30th, 2016 • Enumeral Biomedical Holdings, Inc. • Pharmaceutical preparations • Texas

This COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENT (this “Agreement”) is entered into as of January 11, 2016 (the “Effective Date”) by and between Enumeral Biomedical Holdings, Inc., a Delaware corporation with offices at 200 Cambridge Park Drive, Cambridge, MA 02140 (with its subsidiaries, “Enumeral”), and The University of Texas M. D. Anderson Cancer Center, a member institution of The University of Texas System (“System”) and an agency of the State of Texas, with offices at 1515 Holcombe Blvd., Houston, Texas 77030 (“MDACC”). Each of MDACC and Enumeral is sometimes referred to individually herein as a “Party” and collectively as the “Parties”.

March 24, 2016 Anhco Nguyen, Ph.D. c/o Enumeral Biomedical Holdings, Inc.
Enumeral Biomedical Holdings, Inc. • March 30th, 2016 • Pharmaceutical preparations
AMENDMENT NO. 1 TO STUDY AGREEMENT Between Merck Sharp & Dohme Corp. and Enumeral Biomedical Holdings Inc.
Study Agreement • March 30th, 2016 • Enumeral Biomedical Holdings, Inc. • Pharmaceutical preparations

This Amendment No. 1 to Study Agreement (the “Amendment”) is made as of February 16, 2016, by and between Merck Sharp & Dohme Corp., a New Jersey corporation, having a place of business at One Merck Drive, Whitehouse Station, NJ 08889-0100 (“Merck”) and Enumeral Biomedical Holdings Inc., a Delaware corporation, having a place of business at 200 CambridgePark Drive, Suite 2000, Cambridge, MA 02140 (“Enumeral”). This Amendment amends that certain Study Agreement, dated as of December 17, 2014, by and between Merck and Enumeral (the “Agreement”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to such terms in the Agreement.

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