0001615774-18-000863 Sample Contracts

BIOFRONTERA AG AND THE BANK OF NEW YORK MELLON
Deposit Agreement • February 6th, 2018 • Biofrontera AG • Pharmaceutical preparations • New York

DEPOSIT AGREEMENT dated as of _____________, 2018 among BIOFRONTERA AG, a stock corporation incorporated under the laws of Germany (herein called the Company), THE BANK OF NEW YORK MELLON, a New York banking corporation (herein called the Depositary), and all Owners and Holders (each as hereinafter defined) from time to time of American Depositary Shares issued hereunder.

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Manufacturing and Supply Agreement (Projekt H 2000)
Manufacturing and Supply Agreement • February 6th, 2018 • Biofrontera AG • Pharmaceutical preparations

This Manufacturing and Supply Agreement (together with its Attachments, which are incorporated herein by reference, the "Agreement") is made on June 1st, 2015 (the "Effective Date") by and between Hapila GmbH, Otto-Schott-Straße 9, 07552 Gera, Germany ("Hapila") and Biofrontera Pharma GmbH, HemmelratherWeg 201, D-51377 Leverkusen, Germany ("Biofrontera"). Hapila and Biofrontera are hereinafter also referred to individually as "Party" or collectively as "Parties".

Mandate Agreement
Mandate Agreement • February 6th, 2018 • Biofrontera AG • Pharmaceutical preparations

in relation to support during a cash capital increase as part of a subscription offer, and potentially a private placement for shares not subscribed for by shareholders, of up to 6,000,000 New Shares with subsequent admittance to quotation on the stock market in the Regulated Market of the Düsseldorf Stock Exchange and the Deutsche Börse.

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