0001626199-22-000057 Sample Contracts

CERTAIN INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED. OMISSIONS ARE DESIGNATED AS [***].

Option and License Agreement • August 11th, 2022 • Alpine Immune Sciences, Inc. • Pharmaceutical preparations

• Contract Type
  Option and License Agreement
• Filed
  August 11th, 2022
• Company
  Alpine Immune Sciences, Inc.
• Industry
  Pharmaceutical preparations

This letter serves to memorialize the agreement between AbbVie and Alpine to replace Schedule 1.157 of the Agreement with the Schedule 1.157 attached to this letter as Exhibit A.

ALPINE IMMUNE SCIENCES, INC. EXECUTIVE EMPLOYMENT AGREEMENT

Executive Employment Agreement • August 11th, 2022 • Alpine Immune Sciences, Inc. • Pharmaceutical preparations • Washington

• Contract Type
  Executive Employment Agreement
• Filed
  August 11th, 2022
• Company
  Alpine Immune Sciences, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Washington

THIS EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) is entered into between Alpine Immune Sciences, Inc. (the “Company”), and Andrew Sandler (“Executive”) (collectively referred to as the “Parties” or individually as a “Party”).