0001628280-19-003037 Sample Contracts

LEASE AGREEMENT
Lease Agreement • March 18th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations

THIS LEASE AGREEMENT (this “Lease”) is made this 25th day of February, 2019, between ARE-SD REGION NO. 44, LLC, a Delaware limited liability company (“Landlord”), and REGULUS THERAPEUTICS INC., a Delaware corporation (“Tenant”).

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FOURTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 18th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations • California

THIS FOURTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT (this “Amendment”) is made effective as of November 5, 2018 (the “Fourth Amendment Date”) by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (in its individual capacity, “Oxford”; and in its capacity as Collateral Agent, “Collateral Agent”), the Lenders listed on Schedule 1.1 of the Loan Agreement (as defined below) from time to time including Oxford in its capacity as a Lender (each a “Lender” and collectively, the “Lenders”) and REGULUS THERAPEUTICS INC., a Delaware corporation with offices located at 10614 Science Center Dr., San Diego, California 92121 (“Borrower”).

AGREEMENT
Lease Agreement • March 18th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations • California

THIS AGREEEMENT ("Agreement") is made and entered into as of the 19th day of February 2019, by and between NITTO BIOPHARMA, INC., a Delaware corporation ("Nitto"), and REGULUS THERAPEUTICS INC., a Delaware corporation ("Regulus").

SECOND AMENDMENT TO LEASE
Lease • March 18th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations

THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of February 25th, 2019, by and between ARE-SD REGION NO. 44, LLC, a Delaware limited liability company (“Landlord”), and REGULUS THERAPEUTICS INC., a Delaware corporation (“Tenant”).

SIXTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 18th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations • California

THIS SIXTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT (this “Amendment”) is made effective as of March 7, 2019 (the “Sixth Amendment Date”) by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (in its individual capacity, “Oxford”; and in its capacity as Collateral Agent, “Collateral Agent”), the Lenders listed on Schedule 1.1 of the Loan Agreement (as defined below) from time to time including Oxford in its capacity as a Lender (each a “Lender” and collectively, the “Lenders”) and REGULUS THERAPEUTICS INC., a Delaware corporation with offices located at 10614 Science Center Dr., San Diego, California 92121 (“Borrower”).

Contract
Collaboration and License Agreement • March 18th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations • New York
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