0001628280-20-000685 Sample Contracts

Denali Therapeutics Inc. Common Stock, par value $0.01 per share Underwriting Agreement
Underwriting Agreement • January 29th, 2020 • Denali Therapeutics Inc. • Biological products, (no disgnostic substances) • New York

Denali Therapeutics Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated in this agreement (this “Agreement”), to issue and sell to the Underwriters named in Schedule I hereto (the “Underwriters”) an aggregate of 7,826,087 shares (the “Firm Shares”) and, at the election of the Underwriters, up to 1,173,913 additional shares (the “Optional Shares”) of the Common Stock, par value $0.01 per share (“Stock”) of the Company (the Firm Shares and the Optional Shares that the Underwriters elect to purchase pursuant to Section 2 hereof being collectively called the “Shares”).

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