0001628280-22-004300 Sample Contracts

DENALI THERAPEUTICS INC. Common Stock ($0.01 par value) Having an Aggregate Offering Price of up to $400,000,000 Equity Distribution Agreement
Terms Agreement • February 28th, 2022 • Denali Therapeutics Inc. • Biological products, (no disgnostic substances) • New York

Denali Therapeutics Inc., a Delaware corporation (the “Company”) confirms its agreement (this “Agreement”) with Goldman, Sachs & Co. LLC (“Goldman”), SVB Securities LLC (“SVB Securities”) and Cantor Fitzgerald & Co. (“Cantor”) (each a “Manager” and, collectively, the “Managers”) as follows:

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