0001628280-22-006093 Sample Contracts

SEVERANCE AND CHANGE IN CONTROL AGREEMENT
Severance and Change in Control Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

THIS SEVERANCE AND CHANGE IN CONTROL AGREEMENT (the “Agreement”), made this 10th day of March 2021 (the “Effective Date”), is entered into by AVEO Pharmaceuticals, Inc., a Delaware corporation with its principal place of business at 30 Winter Street Boston, MA 02108 (the “Company”), and Michael Ferraresso (the “Employee”).

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LICENSE AGREEMENT BY AND BETWEEN EUSA PHARMA (UK) LIMITED AND AVEO PHARMACEUTICALS, INC Dated: December 18, 2015
License Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This LICENSE AGREEMENT (this “Agreement”) is entered into as of December 18, 2015 (the “Effective Date”) by and between EUSA PHARMA (UK) LIMITED, with its principal offices at Breakspear Park, Breakspear Way, Hemel Hempstead, HP24TZ, United Kingdom (“Partner”), and AVEO PHARMACEUTICALS, INC., a Delaware corporation with its principal offices at One Broadway, 14th Floor, Cambridge, MA 02142 (“AVEO”). AVEO and Partner may be referred to herein each, individually, as a “Party” or, collectively, as the “Parties.”

NON-COMPETITION AND NON-SOLICITATION AGREEMENT
Non-Competition and Non-Solicitation Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

This Non-Competition and Non-Solicitation Agreement (the “Agreement”) is made between AVEO Pharmaceuticals, Inc. a Delaware corporation (hereinafter referred to collectively with its subsidiaries as the “Company”), and the undersigned employee (the “Employee”).

REVOCABLE TEMPORARY LICENSE AGREEMENT
Revocable Temporary License Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations

dated as of November 17, 2021 is entered into between TFC 30 Winter LLC, a Massachusetts limited liability company (“Licensor”), and AVEO Pharmaceuticals, Inc., a Delaware corporation (“Licensee”).

SEVERANCE AND CHANGE IN CONTROL AGREEMENT
Severance and Change in Control Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

WHEREAS, the Company has determined that appropriate steps should be taken to reinforce and encourage the employment and dedication of the Employee and the Employee's efforts to maximize the Company's value.

FIRST AMENDMENT TO SUBLEASE AGREEMENT
Sublease Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations

This First Amendment to Sublease Agreement (this “Agreement”) is dated as of November 17, 2021 (“Effective Date”) by and between Commonwealth Care Alliance, Inc., a Massachusetts not-for-profit corporation (“Sublandlord”; sometimes also referred to as “Tenant”), and AVEO Pharmaceuticals, Inc., a Delaware corporation (“Subtenant”).

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 14th, 2022 • Aveo Pharmaceuticals, Inc. • Pharmaceutical preparations • California

THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (as amended by that certain (i) First Amendment to Amended and Restated Loan and Security Agreement dated as of August 7, 2020 (the “First Amendment”), (ii) Second Amendment to Amended and Restated Loan and Security Agreement dated as of February 1, 2021 (the “Second Amendment”) and (iii) Third Amendment to Amended and Restated Loan and Security Agreement dated as of March 8, 2022 (the “Third Amendment”)) is made and dated as of December 28, 2017 and is entered into by and between AVEO PHARMACEUTICALS, INC., a Delaware corporation, and each of its Qualified Subsidiaries (hereinafter collectively referred to as “Borrower”), the several banks and other financial institutions or entities from time to time parties to this Agreement (collectively, referred to as “Lender”) and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and Lender (in such capacity, “Agent”).

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