0001628280-22-026765 Sample Contracts

Denali Therapeutics Inc. Common Stock, par value $0.01 per share Underwriting Agreement
Underwriting Agreement • October 20th, 2022 • Denali Therapeutics Inc. • Biological products, (no disgnostic substances) • New York

Goldman Sachs & Co. LLC J.P. Morgan Securities LLC As representatives (the “Representatives”) of the several Underwriters named in Schedule I hereto, c/o Goldman Sachs & Co. LLC 200 West Street, New York, New York 10282-2198 c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 Ladies and Gentlemen:

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