0001628280-23-009061 Sample Contracts

TENTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 23rd, 2023 • Regulus Therapeutics Inc. • Pharmaceutical preparations

THIS TENTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT (this “Amendment”) is made effective as of August 25, 2020 (the “Amendment Date”) by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (in its individual capacity, “Oxford”; and in its capacity as Collateral Agent, “Collateral Agent”), the Lenders listed on Schedule 1.1 of the Loan Agreement (as defined below) from time to time including Oxford in its capacity as a Lender (each a “Lender” and collectively, the “Lenders”) and REGULUS THERAPEUTICS INC., a Delaware corporation with offices located at 10628 Science Center Dr., Suite 225, San Diego, California 92121 (“Borrower”).

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