0001654954-19-011320 Sample Contracts

●] Shares MONOPAR THERAPEUTICS INC. Common Stock UNDERWRITING AGREEMENT
Underwriting Agreement • October 1st, 2019 • Monopar Therapeutics • Pharmaceutical preparations • New York

Monopar Therapeutics Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several underwriters named in Schedule I hereto (the “Underwriters”) for whom you are acting as representative (the “Representative”) an aggregate of [●] shares (the “Firm Shares”) of the common stock, par value $0.001 per share, of the Company (“Common Stock”). The Company also proposes to sell to the several Underwriters, for the sole purpose of covering over-allotments in connection with the sale of the Firm Shares, at the option of the Underwriters, up to an additional [●] shares of Common Stock (the “Option Shares”). The Firm Shares and the Option Shares are hereinafter referred to collectively as the “Shares”.

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Employment Agreement • October 1st, 2019 • Monopar Therapeutics • Pharmaceutical preparations

First Amendment to Employment Agreement between Kim R. Tsuchimoto (“Executive”) and Monopar Therapeutics Inc. (“Company”) dated November 1, 2017. The following amendments are made effective March 1, 2018. All other unrevised sections remain in full force.

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