0001662252-16-000190 Sample Contracts

FIRST AMENDMENT TO DISTRIBUTION, LICENSE AND SUPPLY AGREEMENTentered into as of the 22ndday of June, 2016 (the "First Amendment") BETWEEN: KNIGHT THERAPEUTICS INC., a corporation
Distribution Agreement • July 14th, 2016 • Ember Therapeutics, Inc. - Ny • Pharmaceutical preparations • New York

WHEREAS Ember and Knight are parties of a certain Distribution, License and Supply Agreement (the "Distribution Agreement"), made as of the 3rd day of August, 2015.

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