AUC0-inf definition

AUC0-inf means “area under the curve,” which is a way of measuring the total amount of the active drug in a subject’s system over a period of time from administration (“0”) to the time that the drug is no longer present in the subject’s body (“infinity”). ’760 patent, col. 11, ll. 12–23.
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AUC0-inf means the total area under the plasma concentration-time curve from time zero to infinity. In other words, AUC(0-inf) represents the total amount of drug delivered by the dose in question. A POSA would use Zegerid’s AUC(0-inf) data to inform their understanding of the AUC produced from hours zero to ten, and ten to twenty-four. The figures accompanying the AUC data in the Zegerid label show little absorption after hour eight. Ex. 1010 at 4, Figures. The Zegerid label also reported that, “absorption of omeprazole is rapid, with mean peak plasma levels of omeprazole occurring at around 30 minutes (range 10 to 90 minutes) after a single dose or repeated once-daily administration.” Ex. 1010 at 4.
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Related to AUC0-inf

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  • the Scottish Infected Blood Support Scheme means the scheme of that name administered by the Common Services Agency (constituted under section 10 of the National Health Service (Scotland) Act 1978(b));

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