Clinically actionable definition

Clinically actionable means that there are established therapeutic or preventive interventions or other available actions that have the potential to change the clinical course of the disease/condition, or lead to an improved health outcome.
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Examples of Clinically actionable in a sentence

  • Clinically actionable findings for the purpose of this study are defined as disorders appearing in the American College of Medical Genetics and Genomics recommendations for the return of incidental findings that is current at the time of primary analysis.

  • Clinically actionable findings for this study are defined as disorders appearing in the American College of Medical Genetics and Genomics recommendations for the return of incidental findings that is current at the time of primary analysis.

  • Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing.

  • The legal next of kin would be offered genetic counseling that would include the distinction between a clinical and research finding and would be offered the opportunity to have those findings confirmed in a living relative of the patient.Note: Clinically actionable findings for the purpose of this study are defined as disorders appearing in the American College of Medical Genetics and Genomics recommendations for the return of incidental findings that is current at the time of primary analysis.

  • Clinically actionable findings should be communicated to research participants through caregivers, unless participants have objected to being recontacted during informed consent procedures.

  • Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing.

  • Case study 3: Clinically actionable variants an individual genome To identify variants with potential for clinical relevance, we applied filters to the whole genome sequence variation of a phenotypically normal individual obtained from the Personal Genome Project (Profile hu3BDC4B, https://www.personalgenomes.org)18.

  • Clinically actionable alterations to be included in the primary analysis: Exon 19 deletions, L858R, L861Q, G719X and S768I APPENDIX II Table 6.

  • Clinically actionable “Omics”: the personalome for Precision Therapy.

  • Clinically actionable alterations are characterized as those associated with FDA-approved therapeutics for on- or off- label use, as well as pathogenic or likely pathogenic germline variations.

Related to Clinically actionable

  • Regulatory Action means an administrative, regulatory, or judicial enforcement action, proceeding, investigation or inspection, FDA Form 483 notice of inspectional observation, warning letter, untitled letter, other notice of violation letter, recall, seizure, Section 305 notice or other similar written communication, injunction or consent decree, issued by the FDA or a federal or state court.

  • Commercially Sensitive Information means the Information (i) listed in the Commercially Sensitive Information Schedule; or (ii) notified to the Authority in writing (prior to the commencement of this Contract) which has been clearly marked as Commercially Sensitive Information comprised of information:

  • medically approved means certified by a medical practitioner;

  • Study means the investigation to be conducted in accordance with the Protocol.

  • Technically Feasible refers solely to technical or operational concerns, rather than economic, space, or site considerations.

  • Biological agent shall mean any pathogenic (disease producing) micro-organism(s) and/or biologically produced toxin(s) (including genetically modified organisms and chemically synthesized toxins) which cause illness and/or death in humans, animals or plants.

  • Sexually oriented business means an adult arcade, adult bookstore or adult video store, adult cabaret, adult motel, adult motion picture theater, adult theater, escort agency, nude model studio, or sexual encounter center.

  • Financially Literate means the ability to read and understand a set of financial statements that present a breadth and level of complexity of accounting issues that are generally comparable to the breadth and complexity of the issues that can reasonably be expected to be raised by the Corporation’s financial statements.

  • Third Party Action means any suit or proceeding by a person or entity other than a Party for which indemnification may be sought by a Party under Article VII.