Mean kinetic temperature definition

Mean kinetic temperature means the calculated temperature at which the total amount of degradation over a particular period is equal to the sum of the individual degradations that would occur at various temperatures.
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Examples of Mean kinetic temperature in a sentence

  • Mean kinetic temperature (MKT) is defined by the ICH as ‘A single derived temperature that, if maintained over a defined period of time, affords the same thermal challenge to a drug substance or drug product as would be experienced over a range of both higher and lower temperatures for an equivalent defined period.

  • Table 4: Bracketing (of one factor) and Matrixing (with three-fourths time points) Annex IIMean Kinetic Temperature Mean kinetic temperature (MKT) is defined as a single derived temperature which, if maintained over a defined period, would afford the same thermal challenge to a drug substance or drug product as would have been experienced over a range of both higher and lower temperatures for an equivalent period.

  • Tk = MKT in ºK ΔH = Heat of activation / activation energy R = Universal gas constant (8.3144 Ti = temperature in ºK # 10-3 kJ.Mole-1 # ºK-1) n = Total number of equal time periods over which data are collected Mean kinetic temperature refers to a reference point, which can be calculated from a series of temperatures.

  • Mean kinetic temperature (MKT) is a simplified way of expressing the overall effect of temperature fluctuations during storage or transit of perishable goods.

  • Post-initialization value: i (0), Details: MKT Active Energy, expressed in kJ/mole, is used for calculation the Mean kinetic temperature (MKT).

  • The four Climatic Zones Criteria used to classify a site according to climatic zone Criteria Measured and calculated climatic data for Atlanta January7 a.m. 14 p.m. Mean kinetic temperature: Tmkt∆E/R= e-∆E/RT1 + e-∆E/RT2 + e-∆E/RTn-ln nIf a mean temperature is calculated and the difference between two temperatures is > 5°C the mean kinetic temperature should be calculated instead of the arithmetic mean temperature.

Related to Mean kinetic temperature

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