MOE Gapmer definition

MOE Gapmer means a single stranded antisense oligonucleotide of less than [***] nucleotides (i) wherein all of the backbone linkages are modified by adding a sulfur at the non-bridging oxygen (phosphorothioate) and (ii) comprising a region of at least [***] unsubstituted 2′-deoxy nucleotides with the remaining nucleotides contain a 2′-O-(methoxyethyl) substitution at the 2′ position.
Sample 1Sample 2Sample 3
MOE Gapmer means a single stranded ASO of less than [***] nucleotides (i) wherein [***] backbone linkages are modified by substituting a sulfur at the non-bridging oxygen (phosphorothioate) and (ii) comprising a region of at least [***] unsubstituted 2’ deoxy nucleotides with the remaining nucleotides having a 2’-O-(methoxyethyl) substitution at the 2’ position.
Sample 1Sample 2
MOE Gapmer means a single-stranded ASO of less than 25 nucleotides comprising a region of at least 6 unsubstituted 2’ deoxy nucleotides with the remaining nucleotides having a 2’-O-(methoxyethyl) substitution at the 2’ position.
Sample 1

Examples of MOE Gapmer in a sentence

  • The observation of arteritis/periarteritis is mentioned in the SPC section 5.3.In the reproductive toxicity studies some slight alterations were noted, such as a slight increase in total major fetal abnormalities in the low and medium dose in the combined fertility and teratology study.

  • After the Project Plan has been completed, the Parties will append to this Agreement the specific sequence and chemistry of each MOE Gapmer which constitutes the active pharmaceutical ingredient in each Product.

  • The Project Plan consists of and includes all work required to allow for a decision on whether or not to proceed with a MOE Gapmer to IND-enabling toxicology studies.

  • OncoGenex will perform in vitro and in vivo analyses as needed to identify a lead MOE Gapmer.


More Definitions of MOE Gapmer

MOE Gapmer means “2´MOE Gapmers” or an antisense phosphorothioate oligonucleotide of 15-30 nucleotides wherein all of the backbone linkages are modified by adding a sulfur at the non-bridging oxygen (phosphorothioate) and a stretch of at least 10 consecutive nucleotides remain unmodified (deoxy sugars) and the remaining nucleotides contain an O´-methyl O´-ethyl substitution at the 2´ position (MOE).
Sample 1

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