Target Gene definition

Target Gene means the specific gene that is the target for disruption. “Targeting Vectors” means DNA constructs used to produce ES Cells.
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Target Gene means the specific gene that is the target for disruption.
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Target Gene means each of Fabry Target Gene, Pompe Target Gene, [***] Target Gene, Additional Target Gene, subject to Section 5.1, and Option Target Gene, subject to Section 5.2 (collectively, the “Target Genes”).
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Examples of Target Gene in a sentence

  • Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.

  • Lineage-Specific Genome Architecture Links Enhancers and Non- coding Disease Variants to Target Gene Promoters.

  • Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.

  • Maheshri, A Regulatory Role for Repeated Decoy Transcription Factor Binding Sites in Target Gene Expression.

  • Insulin-like Growth Factor-1 Impacts p53 Target Gene Induction in UVB-irradiated Keratinocytes and Human Skin.

  • Collectively, these results showed that Alkbh5 expression in melanoma modulates metabolite and cytokine content with the most significant change of lactate in TIF, suggesting another mechanism by which m6A demethylase could modulate the in- filtration of immune cells during anti–PD-1/GVAX treatment.MEDICAL SCIENCESMct4/Slc16a3, an Alkbh5 Target Gene, Is Involved in Regulating Extracellular Lactate Concentration, Tregs, and MDSC Accumulation in the TME.

  • The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.

  • The Drug Target Gene Set Hallmark view outperforms data–specific views in Irinotecan and Panobinostat sensitivity predictions.

  • Manoli I, Hanh Le H, Alesci S, McFann KK, Su Y, Kino T, Chrousos GP, and Blackman MR (2005) Monoamine Oxidase-A is a Major Target Gene for Glucocorticoids in Human Skeletal Muscle Cells: Induction of Gene and Oxidative Activity and Relevance to Glucocorticoid- Mediated Myopathy.

  • For most compounds the Drug Target Gene Set Hallmark is more accurate than the Oncogenic and Immunologic.


More Definitions of Target Gene

Target Gene means (i) a gene which has been linked to a particular area of a chromosome and which is believed to be involved in or associated with the pathogenesis of brain cancer or prostate cancer and which has been selected by the research steering Committee (as defined in Section 2.3) as a target for Discovery in the Research Program and (ii) the MMAC1 brain cancer gene.
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Target Gene means a gene or sequence that is described, referenced or otherwise included in the DeltaBase Information by Deltagen.
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Target Gene means the [***] or any other gene, the Modulation of which would lead to the Treatment of [***].
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Target Gene means the [ * ] and which is included in a Phenotype Set in accordance with Exhibit D that is Delivered to Merck by Deltagen hereunder as part of the DeltaBase Information.
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Target Gene means [ * ].
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Related to Target Gene

  • KPI Target means the acceptable performance level for a KPI as set out in each KPI;

  • Target means Trans-European Automated Real-time Gross Settlement Express Transfer payment system.

  • TARGET 2 means the Trans-European Automated Real-time Gross Settlement Express Transfer payment system which utilizes a single shared platform and which was launched on November 19, 2007.

  • Collaboration Target means the Initial Collaboration Targets set forth on Exhibit F and any Additional Target or Substitute Target that is selected in accordance with Section 3.3 of this Agreement.

  • Soft Target means a target that will suffer minimum damage and cause minimum damage to the subject vehicle in the event of a collision.

  • Targets means pre-agreed values to be achieved at the end of the period in relation to the result indicators included under a specific objective;

  • Target Population means persons with low incomes who have one or more disabilities, including mental illness, HIV or AIDS, substance abuse, or other chronic health condition, or individuals eligible for services provided pursuant to the Lanterman Developmental Disabilities Services Act (Division 4.5 (commencing with Section 4500) of the Welfare and Institutions Code) and may include, among other populations, adults, emancipated minors, families with children, elderly persons, young adults aging out of the foster care system, individuals exiting from institutional settings, veterans, and homeless people.

  • Target Audience means users on the Criteo Network who will be targeted with relevant performance advertising Product Ads based on the Criteo Technology.

  • Development Milestone Event shall have the meaning set forth in Section 9.2(a).

  • Anti-Static Product means a product that is labeled to eliminate, prevent, or inhibit the accumulation of static electricity. “Anti-Static Product” does not include “Electronic Cleaner,” “Floor Polish or Wax,” “Floor Coating,” and products that meet the definition of “Aerosol Coating Product” or “Architectural Coating.”

  • Acquisition Target means any Person becoming a Subsidiary of the Company after the date hereof; any Person that is merged into or consolidated with the Company or any Subsidiary of the Company after the date hereof; or any Person with respect to which all or a substantial part of that Person’s assets are acquired by the Company or any Subsidiary of the Company after the date hereof.

  • Collaboration Compound means any of the following: (a) FG-4592, (b) any HIF Compound (other than FG-4592) that is added to this Agreement pursuant to Section 3.6, and (c) any salts, esters, complexes, chelates, crystalline and amorphous morphic forms, pegylated forms, enantiomers (excluding regioisomers), prodrugs, solvates, metabolites and catabolites of any of the foregoing ((a) or (b)).

  • Back-Up Compound means, with reference to any particular Development Candidate or Drug Product Candidate, a Compound which (a) has the same principal mode of action (i.e., Potentiator or Corrector) as that Development Candidate or Drug Product Candidate; and (b) was among the group of Compounds, identified by VERTEX as potential additional lead molecules having the same principal mode of action, from which the Development Candidate was selected.

  • Antibody means a molecule or a gene encoding such a molecule comprising or containing one or more immunoglobulin variable domains or parts of such domains or any existing or future fragments, variants, modifications or derivatives thereof.

  • Milestone Event has the meaning set forth in Section 8.4.

  • Antigen means a substance recognized by the body as being foreign; it results in the production of specific antibodies directed against it.

  • Milestone Events has the meaning set forth in Section 3.3 (Milestone Payments).

  • Milestone 1 means achievement of annual Net Sales of at least $20,000,000 during the Calendar Year ending on December 31, 2021.

  • Development Candidate means a Compound that meets the Development Candidate Criteria for the initiation of a Development Program for the treatment of CF, and which is the subject of a notice from Vertex to CFFT that Vertex intends to commence formal pre-clinical development of the Compound in the Field pursuant to the provisions of Section 3.1 hereof.

  • Development Milestone Payment shall have the meaning set forth in Section 9.2(a).

  • Collaboration Product means a pharmaceutical product containing or comprising Compound in any dosage form alone, or in combination with, one or more other pharmaceutically active ingredients, and any and all Improvements thereto.

  • Opioid antagonist means a drug that binds to opioid

  • Product Candidate means each of MYO-101, MYO-102, MYO-103, MYO-201 and MYO-301, as defined on Exhibit B, in each case in any form or formulation.

  • DNA profile means a letter or number code which represents a set of identification characteristics of the non-coding part of an analysed human DNA sample, i.e. the particular molecular structure at the various DNA locations (loci);

  • Diagnostic Product means In Vitro Diagnostics, In Vivo Diagnostic Agents and any product used for Diagnosis.

  • Milestone 2 means achievement of annual Net Sales of at least $35,000,000 during any Calendar Year ending on or before December 31, 2024.