Vd/F definition
Vd/F. (Liters) as used herein means the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. t is generally defined as the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing. “Vd/F” as used herein is calculated by using the terminal elimination rate constant, which is derived mathematically from the concentration vs time curve to extrapolate a value of plasma concentration at time zero. Volume of distribution for oral drugs is normally expressed as Vd/F or Vz/F. The skilled artisan is familiar with calculating Vd/F or Vz/F.
Examples of Vd/F in a sentence
Analyses of PUF Mo may also be conducted: • Maximum observed concentration (Cmax), time to maximum concentration (tmax), AUC from time 0 to the time of last measurable concentration (AUCt), AUC from time 0 to infinity (AUC∞), apparent terminal-phase elimination rate constant (λz), t½, clearance bioavailability (CL/F), and apparent volume of distribution (Vd/F).
The fu value determined for each subject will be used to calculate the following unbound LOXO-305 PK parameters for each individual subject: Unbound Cmax (Cmax,u), unbound AUC0-t (AUC0-t,u), unbound AUC0-inf (AUC0-inf,u), unbound CL/F (CL/F,u), and unbound Vd/F (Vz/F,u).