Contrast mechanisms associated with Neuromelanin-MRI

Contrast mechanisms associated with Neuromelanin-MRI

Xxxxx Trujillo1,2, Xxxx Summers1, Xxxxxxxx Ferrari3, Xxxxx X. Zucca3, Michela Sturini4, Luca Mainardi2, Xxxxxx Cerutti2, Alex K Smith5,6, Seth A Smith5,6,7, Xxxxx Zecca3, Antonella Costa1

1 Department of Neuroradiology, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, MI, Italy

2 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, MI, Italy

3 Institute of Biomedical Technologies, National Research Council of Italy, Segrate, MI, Italy

4 Department of Chemistry, University of Pavia, Pavia, PV, Italy

5 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA

6 Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

7 Department of Radiology and Radiological Sciences, Xxxxxxxxxx Xxxxxxxxxx, Xxxxxxxxx, XX, XXX

Full postal and email address of the corresponding author:

Xxxxx Xxxxxxxx

Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico Department of Neuroradiology

Xxx X. Xxxxxx 00 00000, Xxxxx, XX, Xxxxx

Email: xxxxx.xxxxxxxx@xxxxxx.xx

Abbreviations: BSA = bovine serum albumin; DS = direct saturation; LC = locus coeruleus; MT =

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