OVEREENKOMST 2018 ter uitvoering van een studie “Nalevingscontrole en inhoudelijke evaluatie van de registratie van stoffen geproduceerd in nanoparticulaire toestand volgens KB 27 mei 2014”
TRACE ELEMENTS AN D NANOM ATERIALS
OVEREENKOMST 2018 ter uitvoering van een studie “Nalevingscontrole en inhoudelijke evaluatie van de registratie van stoffen geproduceerd in nanoparticulaire toestand volgens KB 27 mei 2014”
“NanoRegister Evaluation”
1/11/2018 – 30/10/2020
A N N U A L R E P O R T
P H A S E 1 - T R A D E Y E A R 2 0 1 7
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M A Y 2 0 2 0
Xxxxxx Xxxxxxxxxxx, Xxxxxxx Xxxxxxxxx and Xxx Xxxx
Sciensano Juliette Xxxxxxxxxxxxx 00, 0000 Xxxxxxx, T + 32 2 642 51 11, T press + 32 2 642 54 20, xxxx@xxxxxxxxx.xx, xxx.xxxxxxxxx.xx
W H O W E A R E
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SCIENSANO can count on more than 700 staff members who commit themselves, day after day, to achieving our motto: Healthy all life long. As our name suggests, science and health are central to our mission. Sciensano’s strength and uniqueness lie within the holistic and multidisciplinary approach to health. More particularly we focus on the close and indissoluble interconnection between human and animal health and their environment (the “One health” concept). By combining different research perspectives within this framework, Sciensano contributes in a unique way to everybody’s health.
For this, Sciensano builds on the more than 100 years of scientific expertise of the former Veterinary and Agrochemical Research Centre (CODA-CERVA) and the ex-Scientific Institute of Public Health (WIV-ISP).
Sciensano
February 2021 • Brussels • Belgium
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Stella Mathioudaki1
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Xxxxxxx Verleysen1
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Jan Mast1
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1 Sciensano, Scientific Direction Chemical and Physical Health Risks, Service Trace Elements and Nanomaterials, Brussels
Contact person: Xxx Xxxx • T+32 2 3790553 • xxx.xxxx@xxxxxxxxx.xx
Please cite as: Xxxxxx Xxxxxxxxxxx, Xxxxxxx Xxxxxxxxx, Xxx xxxx. NanoRegister Evaluation: "Compliance control and substantive evaluation of the registration of substances produced in nanoparticulate state according to Royal Decree of 27 May 2014” - Trade Year 2017. Brussels: Sciensano; 2021.
DOI: 10.25608/njks-f383
TABLE OF CONTENTS
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THE BELGIAN REGISTER OF NANOMATERIALS 7
2. Key concepts and definitions 8
2.1. Definition of a substance in a nanoparticulate state 8
2.2. Exempted from registration 8
2.3. Deadlines for registration 9
2.5. Types of registrations 10
2.6. Definition of roles in the supply chain 10
1. Description of the project 12
2. Main Goals of the project 12
3. Scope of the present report 13
2.2. Analysis of the different types of registrations 17
2.3.1. Complete registrations 17
2.3.1.1. Chemical identification 17
2.3.1.2. Particle size and shape 18
2.3.1.3. Agglomerates and aggregates 19
2.3.1.4. Coating, impurities and crystallographic analysis 21
2.3.1.5. Specific surface area and surface charge 22
2.3.1.6. Sector of use of the material 22
2.3.2. Simplified registrations 24
2.3.3. Statistical analysis of the compliance database 24
2.3.4. Evaluation of the determination methods used in the NanoRegister. 28
2.3.5. Limited registrations 30
3. Suggestions and solutions 36
LIST OF ABBREVIATIONS
Symbol | Signification |
AFM | Atomic Force Microscopy |
XXX | Xxxxxxxx–Xxxxxx–Teller |
CAS (number) | Chemical Abstracts Service |
DLS | Dynamic Light Scattering |
EC | European Commission |
EC (number) | Enzyme Commission |
EM | Electron Microscopy |
EU | European Union |
FESEM | Field Emission Scanning Electron Microscopy |
GC | Gas Chromatography |
HPLC | High-Performance Liquid Chromatography |
ICP-MS | Inductively Coupled Plasma - Mass Spectrometry |
ICP-OES | Inductively Coupled Plasma - Optical Emission Spectroscopy |
NM | Nanomaterial |
NP | Nanoparticle |
REACH (number) | Registration, Evaluation, Authorization and Restriction of Chemicals |
SD | Standard Deviation |
SEM | Scanning Electron Microscopy |
STEM | Scanning Transmission Electron Microscopy |
TEM | Transmission Electron Microscopy |
XRD | X-Ray powder Diffraction |
This project evaluates the registration of materials produced in a nanoparticulate state according to the KB of May 27th 2014. The Royal Decree concerning the placing on the market of substances manufactured in nanoparticulate state was signed on May 27th, 2014, published on September 24th, 2014, and modified on December 22nd, 2017. According to this Royal Decree, the deadlines for registration of substances and mixtures manufactured in a nanoparticulate state were January 1st, 2016 and January 1st, 2018, respectively. The registration software was launched on September 15th, 2015. Phase 1 of the project included the evaluation of the registrations of the trade year 2017 and was successfully completed and reported in this document. As a next step, data extraction and statistical analysis methods will be applied to evaluate the registrations of the trade year 2018.
For 2017, the completion of obligatory fields within the registration dossiers (“compliance check”) and the quality of the content of the submitted dossiers were assessed.
The compliance check assessed for each dossier if all obligatory fields were completed by the applicants. For the simplified registrations it was checked if the declaration of honour was added to the dossier. A derived, “compliance” database was constructed and a statistical analysis of the data in the “compliance“ database was done.
The content of the register was evaluated per parameter, and included listing and evaluating the methods used for measuring each registered parameter, and the number of different materials and their quantity. For the complete dossiers, it was assessed per parameter if the reported physicochemical data are in accordance with the current technical possibilities.
The results of the assessment and a list of recommendations for further optimization of the register based on this assessment are reported in this document.
The main results for the trade year 2017 are summarized as:
• During the trade year 2017, 454 registrations were submitted.
• Evaluation of the submitted registrations showed that most of the applicants provided the requested information for the materials they registered, and the declaration of honour for the simplified registrations was undersigned (100%).
• In the complete registrations, most of the obligatory information was present, as indicated from the compliance check, although specific parameters, as for instance the uncertainties of size measurements, were systematically missing (15%).
• In 92% of the limited registrations the applicants provided the previous registration numbers and the compliance check revealed that the physicochemical characteristics of the substances were present (100%).
• In total 179 different materials (chemical substances) were identified that are presented in the Annex. The chemical identification makes no distinction between the possible differences in the physicochemical properties of these substances.
• Evaluation of the determination methods (complete registrations) used to characterize the physicochemical characteristics of the nanoparticulate materials showed that the applicants employed well established methods, such as EM (67%) for the characterization of the constituent particle size and BET (94%) for the calculation of the mean specific surface area.
• The total quantity of substances in the nanoparticulate state, which was introduced on the Belgian market in 2017 was 201429533.6 kg (201429.5336 tons) based on the recorded data.
• The substances that were introduced on the Belgian market in a total quantity that is larger than 1000 tons are iron hydroxide oxide yellow, calcium carbonate, diiron trioxide, calcium carbonate treated with stearic acid, silicon dioxide and carbon black. In most of the registrations (78%), the applicants declared quantities that range between 10 and 100000 kg.
• About 46% (190 registrations) of the submitted registrations reported quantities below 1 ton and would therefore be considered to be out of the scope of the REACH-regulation.
THE BELGIAN REGISTER OF NANOMATERIALS
1. Objectives
The Royal Decree concerning the placing of substances produced in nanoparticulate state on the market was signed on the 27th May 2014 [1]. This Royal Decree is based on the one hand on the law of the 21st December 1998 on product standards to promote sustainable production and consumption patterns and on the protection of the environment, public health and workers, and on the other hand on the law of the 4th August 1996 on the well-being of workers in the execution of their works. The creation of the register aims at the following objectives [2]:
• ensuring that the evolution of this innovative technology proceeds in harmony with the protection of human health;
• acquiring better knowledge of the market, the characteristics of the nanomaterials, the potential risk of human exposure to these substances, and of the speed and extent of the evolution towards more complex nanomaterials;
• guaranteeing transparency and strengthening the trust of the public and employees with regard to these substances;
• guaranteeing traceability and therefore offering the government the possibility to intervene in case of a risk for the public health or for the safety of employees;
• introducing a knowledge base that might be necessary for the future regulatory evolution at national and European level with regard to these substances.
Specifically, the register will in particular make it possible to guarantee the traceability of products containing substances produced in nanoparticulate state. The register will:
• make efficient intervention possible if a type of nanomaterial turns out to be dangerous to public health;
• provide the public authorities competent for the safety of employees with the relevant information in order to be able to carry out their duties concerning information, regulation and control in a targeted manner;
• assure, if necessary, that the collected data (non-confidential data or aggregated data) can be made public to inform the public about the increasing presence of nanomaterials on the market, and to avoid misunderstandings and confusion.
Additionally, the register should offer the government the possibility to collect key information about the substances produced in nanoparticulate state that are present on the Belgian market in order to:
• have a basis for scientific research on the possible toxicity of the various types of substances produced in a nanoparticulate state and,
if necessary, be able to focus on the regulations that may be needed to protect public or workers' health from certain types of substances produced in a nanoparticulate state.
2. Key concepts and definitions
2.1. DEFINITION OF A SUBSTANCE IN A NANOPARTICULATE STATE
The definition for a nanoparticulate substance is included in the Royal Decree of the 27th May 2014. This definition is largely based on the European Commission's recommendation for the definition of nanomaterial (Recommendation 2011/696 /EU) [3], but excludes naturally formed nanomaterials and nanomaterials formed as a by-product of human activities.
A substance produced in a nanoparticulate state is considered therefore as "a substance that contains particles either in the unbound state or as an aggregate or agglomerate and of which at least 50% of the particles in the quantified size distribution have one or more external dimensions within the range of one nanometer (1 nm) to one hundred nanometers (100 nm), with the exception of natural, non- chemically modified substances, and substances whose fraction between one nanometer and one hundred nanometers is a by-product of human activities. Fullerenes, graphene flakes and single-walled carbon nanotubes with one or more external dimensions below one nanometer are considered equal to substances produced in the nanoparticulate state.
2.2. EXEMPTED FROM REGISTRATION
In the Royal Decree 27th May 2014, substances produced in a nanoparticulate state are exempt from registration if these substances fall within the scope of another legislation. More specifically, it concerns:
1. The biocides and treated articles that fall within the scope of Regulation (EU) No 528/2012 of the European Parliament and of the Council of 22 May 2012 concerning the market introduction and application of biocides, and the biocides that were registered or for which an authorization has been granted in accordance with the provisions of the Royal Decree of 22 May 2003 concerning the placing on the market and use of biocides.
2. Medicinal products falling within the scope of Regulation (EC) No 726/2004 of the European Parliament and of the Council of 31st March 2004 establishing Community procedures for the authorization and supervision of medicinal products for human and veterinary use and establishing a European Medicines Agency.
3. Medicinal products for human and veterinary use falling within the scope of the Royal Decree of 14th
December 2006 on medicinal products for human and veterinary use.
4. Food, articles and substances intended to come into contact with food, referred to in Article 1, 1° and 2° of the Law of 24th January 1977 on the protection of users' health with regard to food and other products.
5. Feed, as defined in Article 3 of Regulation (EC) No 178/2002 of the European Parliament and of the Council of 28th January 2002 laying down the general principles and requirements of food law, establishing a European Food Safety Authority and establishing procedures for food safety matters.
6. Medicines and medicated feed that fall within the scope of the Act of 21st June 1983 on medicated feed.
7. Processing aids and other products, which may be used for the processing of biologically produced ingredients of agricultural origin, as referred to in Part B of Annex VIII of Commission Regulation (EC) No 889/2008 of 5th September 2008 laying down provisions for implementing Council Regulation (EC) No 834/2007 on organic production and labeling of organic products, with regard to organic production, labeling and control.
8. Pigments, if they are placed on the market in a mixture, an item or a composite item.
2.3. DEADLINES FOR REGISTRATION
The Royal Decree of 27 May 2014 makes a distinction between substances produced in the nanoparticulate state, marketed as:
• substances
• incorporated in a mixture
• integrated into an object or composite object.
Nanoparticulate substances, placed on the market as substances and already available on the market, had to be registered before 1st January 2016.
In the first quarter following 2016, i.e. before the 1st April 2017, the estimates had to be replaced by the current data for the 2016 trading year. This annual update must be carried out in the first three months of the following calendar year.
For substances produced in a nanoparticulate state, placed on the market and processed in a mixture, the same principle is applied, but then one year later.
No deadline has yet been set for substances produced in a nanoparticulate state, integrated into an object or composite object.
Nanoparticulate substances that are placed on the market after the deadlines set in the Royal Decree of 27th May 2014 must be registered before they are effectively placed on the market.
In the software of the Belgian register, the registrant creates his own account and manages his username and password. The account allows the registrant access to the software and can use one or more submit registrations.
In the registry's software, the applicant has the choice between different account types, which are:
- Declarant: according to the provisions of the Royal Decree of 27 May 2014, this is required to register the products that the declarant places on the market. This obligation follows from the fact that the registrant himself places his products on the Belgian market, or from the fact that he acts as a representative for another company. These two types are always considered together in the further report.
- Foreign Supplier: according to the provisions of the Royal Decree of 27 May 2014, this supplier is not obliged to register, because he does not market his products on the Belgian market himself. He has the
possibility to register his products in the register, whereby in addition to the identification of his company, he only records the physical and chemical characteristics of the nanomaterial, as laid down in section 2 of annex 1 to the Royal Decree of 27 May 2014. A foreign supplier does not register quantities, customs, trade names or professional users of its products. The Foreign Supplier can then pass a number of his registrations to his (submitted to registration) customers. They can then register their products using a "limited" registration. In this way, these customers do not have to repeat the physicochemical characteristics of the substances produced in the nanoparticulate state. The term "foreign" mentioned with this type of account indicates that the supplier does not market his products in Belgium (but does market abroad), and does not necessarily have anything to do with the nationality of the company.
Different types of registrations can be submitted in the register by the applicants. In addition to a complete registration, an applicant can register two other types including:
• A limited registration: this concerns the registration of a substance for which the data has already been registered, by another Declarant or by a Foreign Supplier. In this type of registration, the registrant can replace the physicochemical characteristics of the substance in the nanoparticulate state, as laid down in Section 2 of Annex 1 to the Royal Decree of 27 May 2014, by entering the registration number of the registration submitted earlier.
• A simplified registration: this type of registration is used for substances in the nanoparticulate state that are exclusively intended for scientific research and development or for research and development focused on products and processes. In addition to the identification of the Declarant, this type of registration only requires the chemical identification of the substances produced in the nanoparticulate state and a declaration that the substance in question will not be placed on the market for commercial purposes.
The "Foreign Supplier" account type cannot perform simplified registrations.
2.6. DEFINITION OF ROLES IN THE SUPPLY CHAIN
When the Declarant states how much (quantity) of a certain substance is placed on the market in a nanoparticulate state, it can also indicate what role it plays in the supply chain.
The different roles in the supply chain are:
• Producer: produces a substance in the nanoparticulate state, as such or contained in a mixture and places it on the market.
• Distributor: stores substances produced in a nanoparticulate state, as such or contained in a mixture, and places them on the market for third parties.
• Importer: is responsible for the physical introduction on the market of the substance produced in nanoparticulate state, as such or contained in a mixture.
• Formulator: produces mixtures and generally supplies them further in the supply chain or directly to consumers. It mixes the substances produced in a nanoparticulate state, as such or contained in a mixture, without changing the properties of these substances. Examples of such mixtures are paints, adhesives, cosmetics, lubricants, detergents, etc.
• Refiller: brings substances produced in a nanoparticulate state, as such or contained in a mixture, from one container to another, generally during repackaging or to change brand.
• Other: to be specified.
NANOREGISTER EVALUATION
1. Description of the project
The aim of this project is to evaluate the quality of the submitted registrations of substances produced in nanoparticulate state according to the Royal Decree of 27 May 2014. It must also be checked whether all mandatory fields within a registration dossier were entered correctly. The combination of all these mandatory fields corresponds to the complete physicochemical characterization of the substance. The interface of the NanoRegister platform (NANO) is divided in different topics allowing the applicant to introduce general information of the registrant, the chemical identification of the product, the primary particle size and shape, the agglomerates and aggregates size and shape, the existence of coating and its nature, the presence of impurities, the crystallographic phases of the product, the specific surface area and the surface charge. The project’s goal is not to evaluate if the registered measurements are correct or not, but it is to evaluate if the methodology that was used to characterize the physicochemical properties of the substances for each topic was adequate.
2. Main Goals of the project
The goal of the project is to evaluate the registration of substances in nanoparticulate state for the trade year 2017 (1st phase) and for the year 2018 (2nd phase), and to verify the compliance according to the Royal Decree of 27 May 2014. In particular:
• For each complete registration, it will be checked per parameter whether all requested data are present (compliance check).
• For the simplified registrations, it will be checked whether the declaration of honour (signed by the research institute, not the registrant) is present for the nanomaterials listed.
• A derived, compliance database will be set up based on the compliance check.
• The data in the compliance database will be analyzed statistically.
• The data in the NanoRegister will be evaluated evaluation of per parameter by listing the different methods used for meeting each parameter in the NanoRegister.
• The different methods used from the applicants for meeting each parameter in the NanoRegister will be evaluated based on literature data and on the results of research projects such as NanoDefine, NANoREG and To2DeNano projects.
• For registrations using a previous registration number (limited registrations), it will be checked whether the used "previous registration number" is valid and that it contains the data that also apply to the registration concerned.
• For the complete dossiers, it will be evaluated per parameter whether the physicochemical data reported are in accordance with what is currently technically possible.
• A derived, "quality" database will be created and the data will be analyzed statistically.
• A report of the results of will be prepared.
• Recommendations for further optimization of the Belgian NanoRegister based on the evaluation and reporting will be given
3. Scope of the present report
The present report gives and overview of the registrations of the trade year 2017 and aims to contribute to a better understanding of the situation of nanomaterials on the Belgian market. The results are structured as follows:
• Qualitative analysis of a subset of the database and
• Quantitative analysis of the registered data of the trade year 2017, when feasible.
The quantitative analysis of the data is done after filtering to extract the relevant information.
RESULTS
1. Qualitative analysis
An important step was to assure access to the Nano platform, such that the data could be analyzed qualitatively and quantitative.The qualitative examination of the data showed that there are several problematics. Some of them are summarized as follows:
i. Multiple registrations with the same number are present related to updates and adaptations of the data over time.
ii. Overall, the registrations were done in several languages making the comparison and statistics analysis difficult.
iii. For the same registration, completed fields can be found both in French and in English.
iv. Within the same parameter the applicants utilized no harmonized wording.
v. Many of the required parameters leave room for interpretation by the applicants.
vi. Many measurands are asked for and many fields are not completed.
vii. There are no standardized descriptors for size and shape measurands.
viii. The input should be better defined. It cannot be determined whether the absence of information “-” means a negative answer or absence of answer.
ix. Applicants use the input fields for parameters to ask specific questions to NanoRegister staff.
x. Because of missing metadata, for example medium of surface charge, the provided values cannot be interpreted.
xi. Annexes are missing making interpretation of the provided information difficult (no metadata).
xii. It is impossible, also for experts, to interpret many of the inputs provided for many parameters
e.g. 230 V for electron microscopy.
xiii. Certain characterization methods are not suitable and the arguments given to justify these methods are wrong.
xiv. In most cases and for most parameters no measurements uncertainties are indicated.
2. Quantitative analysis
The access to the NANO platform database allowed us to extract the data of the registrations. A specific dataset was extracted, built for Sciensano earlier by DG5, under the name of Reporting/aanpassingen Sciensano. This new dataset contains the limited and complete registrations from 15/09/2015 to 25/01/2019. The date of extraction was 6/01/2020. The qualitative analysis of the extracted data showed that a filtering step was necessary and no evaluation could be done without it. Therefore an algorithm was developed to filter relevant information from this original dataset (Figure 1). This algorithm applies an iterative approach to extract relevant data sorted by category (substance/mixture) and year and identifies unique registrations, resulting in a new dataset useful for statistical analysis.
The original data under the tab “Reporting/aanpassingen Sciensano” consisted of a Table of 3483 lines, each corresponding to a registration (complete or limited) and of 163 columns, which refer to the parameters provided by the applicants. The registrations were sorted by year and only these of the trade year 2017 were kept. This first filtering resulted in a Table of 844 registrations categorized in substances and mixtures. Then, the two categories were treated separately using the developed algorithm (Figure 1). The algorithm identifies the most recent registration automatically and previous registrations of the same substance/mixture are omitted from the dataset. If multiple registrations for the same substance/mixture were introduced on the same day, the registration with the most filled cells is kept. Even though this approach assumes that the registration with the most filled cells is the most complete, it addresses the problem having multiple registrations for the same substance/mixture.
Statistical analysis of the data is performed, when applicable, by using the python libraries pandas and matplotlib.
The simplified registrations, in which the applicants had only to undersign the declaration of honour, were manually checked.
Extract dataset Reporting/aanpassingen from Nano-platform
Sort by registration number
Keep only entries of specific year (e.g. 2017)
Select only one of the two categories (substances or mixtures)
Yes
Is
Keep the entry with the most recent date
registration No
unique?
Are more
Store it in an updated (new) database
No than one entries
Keep the registration with the greater number of filled cells
with same date?
Yes
Perform statistical analysis in the new database
Figure 1. Flowchart of the developed algorithm used for the data filtering of the NanoRegister.
2.2. ANALYSIS OF THE DIFFERENT TYPES OF REGISTRATIONS
From the 227 limited registrations, 209 indicated a previous registration number while 18 did not.. The number of the simplified registrations for the trade year of 2017, for which only the presence of the declaration of honour was checked, was 69. To evaluate the simplified registrations another dataset from the Nano back office platform was downloaded, under the name “All registrations”.
The total number of all registrations that was evaluated (complete, limited and simplified) for the trade year 2017 are 454, number close to the one of the trade year 2016, which is 475 [xxxxx://xxx.xxxxxx.xxxxxxx.xx/xx/xxxxxxxxxxx/xxxxxxxx-xxxxxxxxxx/xxxxxxxxxxxxx/xxxxxxxx].
Table 1. Registrations of the trade year 2017.
Complete | Limited | Simplified |
158 | 227 | 69 |
With previous Reg. No. | Without previous Reg. No. | |
209 | 18 |
The final number of the complete registrations for the trade year 2017 that needs to be evaluated in detail is 158, with 15% registered as mixtures and 85% as substances.
The compliance check is performed for each file per parameter for the complete registrations in order to evaluate whether all data requested from the applicants are present. Below, the data are analyzed and discussed according to the nine main categories, namely the chemical identification, the particle size and shape, the agglomerates and aggregates, the coating, the impurities, the crystallographic structure, the surface charge, the sector of use and the quantity. The applicants introduce the relevant information when registering a material according to these categories. For each category the percentage of input of the key parameters is calculated. For the calculation, the symbol “-” in the exported and filtered database is considered as an absence of answer.
2.3.1.1. Chemical identification
In the category chemical identification, the compliance check is performed for the following subcategories: the chemical name (chemical names are presented in Annex) and chemical formula of the material, and the presence of the CAS number, the REACH number and the EC number. Figure 2 shows the percentage of the applicants registered the relevant information. Most subcategories of the chemical identification show high compliance. For a yet unclear reason, a decreased percentage (67%) is only found for the REACH number registrations.
Figure 2. Compliance check for the category: chemical identification.
2.3.1.2. Particle size and shape
In the category particle size and shape, the compliance check is performed for the following subcategories: the determination method of the size and shape of the material, the shape and the number of dimensions of the material, the median and mean size of dimensions 1, 2 and 3 and the standard deviation of dimensions 1, 2 and 3. Figure 3 and Figure 4 show the percentage of the applicants that registered the relevant information. Additionally, a compliance check is performed for the method motivation, the experimental circumstances, the traceability, the measurement uncertainty, the ability to complete the requested data and the justification, as shown in Figure 5.
Most subcategories of the particle size and shape characteristics show high compliance (>90%). However, a limited number of applicants registered their measurements uncertainties (15%). This could be explained by the fact that completion of the specific field is not obligatory when registering a material.
Figure 3. Compliance check for the category: particle size and shape.
Figure 5. Compliance check for the category: particle size and shape.
2.3.1.3. Agglomerates and aggregates
In the category agglomerates the compliance check is performed for the following subcategories: if the material is sold in form of agglomerates, the estimation method of agglomerates size, the measure type, the mean size and the standard deviation of dimension 1, the shape of agglomerates and the determination method of the agglomerates size. Additionally, compliance check is performed for the method motivation, the experimental circumstances and the traceability, as shown in Figure 6. In most subcategories, the applicants introduced the relevant information and the compliance percentage is very high (≥97%). The only parameter, which shows limited compliance (27%), is related to the shape of agglomerates.
In the category aggregates the compliance check is performed for the following subcategories: if the material is sold in form of aggregates, the measure type, the mean size and the standard deviation of dimension 1, the dimension 1 interval min and max, the shape of agglomerates and the determination method of the agglomerates size. Additionally, compliance check is performed for the method motivation, the experimental circumstances and the traceability, as shown in Figure 7. In most subcategories, the applicants introduced the relevant information and the compliance percentage is very high (≥97%). A decreased percentage (73%) is only found for the aggregates shape registrations.
Figure 6 and Figure 7 show that the applicants had difficulties to register the shapes of the agglomerates and aggregates of their materials. A possible reason for the relatively low compliance in these categories could be that the applicants employed determination methods which cannot provide shape information, such as DLS, rather than descriptive EM methods, which besides size information also gives information about the shape of the materials. Also, the NanoRegister platform lacks specific guidance for the shape categorization of aggregates/agglomerates. To categorize and describe the shape of aggregates and agglomerates, the systems proposed by Xxxxxx-xx-Xxxxxx et al. are suggested [4].
2.3.1.4. Coating, impurities and crystallographic analysis
In the categories coating, impurities and crystallographic analysis the compliance check was performed for the following subcategories: presence of coating, type of coating, presence of impurities, impurities mass concentration, determination method of impurities, crystallographic analysis and crystallographic structure. Figure 8 shows the percentage of the applicants that registered the relevant information. In most subcategories, the applicants introduced the relevant information and the compliance percentage is very high (≥96%). A decreased percentage (76%) is only found for the determination methods of impurities.
2.3.1.5. Specific surface area and surface charge
In the category specific surface area the compliance check is performed for the following subcategories: presence of specific surface area data, mean specific surface area and its standard deviation, determination method of specific surface area, determination method motivation and experimental circumstances. In the category surface charge, the compliance check is performed for the following subcategories: presence of surface charge data, zeta potential, pH and ionic strength. Figure 9 shows the percentage of the applicants that registered the relevant information. In all subcategories for the specific surface area the compliance is very high (≥96%). Contrary, in the subcategories for the surface charge the compliance is limited, and a low number of applicants registered information such as the surface charge zeta potential (75%), the surface charge medium (75%) and the surface charge ionic strength (62%).
Figure 9. Compliance check for the categories: specific surface area and surface charge.
*Percentage of applicants answered positively for specific surface area data. **Percentage of applicants answered positively for surface charge data.
2.3.1.6. Sector of use of the material
In the category sector of use the compliance check is performed for the following subcategories: the sector of use, if the material is used in chemical products, the category of the chemical product, if the material is used in chemical processes, if the material is used in applications where there is environmental release and in which categories, if the material is used in articles and the article’s category. Figure 10 shows the percentage of the applicants that registered the relevant information. More than half of the applicants (51%) answered if their material has a sector of use. The applicants that answered positively, they also registered the relevant information in the subcategories of the sectors of use of their material reaching a compliance of 100%.
2.3.2. Simplified registrations
For the simplified registrations only the presence of the declaration of honour was checked. From the NanoRegister back office platform, a dataset was extracted under the tab Reporting\All registrations (accessed 12/03/2020), to find relative information for the simplified registrations. In total, 69 simplified registrations were submitted for the trade year 2017 and their files were downloaded via the platform. From them, 59 registrations were submitted for the use of single substance and 10 were submitted for multiple substances. The status of the registrations was: 29 registrations were archived, 8 registrations were draft and 32 registrations were submitted. All files of the submitted and archived registrations (61 registrations) were checked, and for all of them (100%) the declaration of honour was undersigned.
2.3.3. Statistical analysis of the compliance database
The compliance check of the complete registrations was performed for the parameters described in paragraph 2.3.1. The derived dataset is then used for the statistical analysis.
The statistical analysis is performed for relevant parameters of the different categories including: the type of shape of the material, the aggregates shape, the type of coating of the material, the determination method of the size and shape of the material, the determination method of the agglomerates size, the determination method of the aggregates size and shape and the determination method of impurities mean specific surface area of the material. Additionally to the statistics, the determination methods are evaluated in 2.3.4.
Figure 11 shows the percentage of the different types of shapes of the registered materials. Among the different choices given to the applicants (sphere, sticks, capsule, flakes, etc.), the option “other” was the most selected (55%). This creates confusion because the applicants had the choice to add new shapes, as shown in Figure 12. Most of these shapes can be attributed to one of the types presented in Figure
11. Describing particles shapes according to standardized nomenclatures as proposed by Xxxxx-xx- Xxxxxx [4], Xxxxxxxx and Xxxxx [5] and Xxxxx-Xxxxxx [6] gives some guidance and avoids such confusion.
Figure 11. Types of shape of the registered materials.
Figure 12. Other types of shape of the registered materials.
Because the applicants have the liberty to describe the aggregates, Figure 13 is very incoherent. This could be avoided by using a categorization, as described by Xxxxx-xx-Xxxxxx [4].
Figure 13. Shapes of aggregates.
Regarding the type of coating, the applicants selected among organic hydrophobic/hydrophilic or inorganic hydrophobic/hydrophilic or other type of coating, with 44% selecting other, 25% organic hydrophobic, 19% inorganic hydrophilic and 12% inorganic hydrophobic.
The percentage of the used determination methods for characterizing the size and shape of the materials is presented in Figure 14. When registering a material in the NanoRegister platform, the applicant could select between three default options (TEM, SEM and AFM) or “Other”, to introduce the determination method of the size and shape of the material.
The two most used methods are TEM, with ~34.2%, and SEM, with ~32.9%. A relative low number of applicants (~2.6%) employed two methods, while ~30.2% of the applicants declared other methods (than the three default methods), including Supplier information (15.1%), DLS (7.6%), Turbidity and Interference Optics (3.4%), no information (2.7%), Centrifuge Photosedimentometry (0.7%) and FESEM (0.7%).
For the determination method of agglomerates, three choices were provided to the applicants, who had to choose if the agglomerates were determined together with the aggregates, if the agglomerates were determined separately from the aggregates or if the agglomerates were not at all determined.
52% of the applicants registered that the size of agglomerates were determined together with the size of aggregates, 34% that the size of agglomerates was not determined and 13% that the size of agglomerates was determined separately from the aggregates size.
For the determination methods of aggregates, the applicants were free to introduce the determination method they used (no default options were provided in the platform). Figure 15 depicts the percentage of the different methods used to determine the shape and the size of aggregates. Among them, the most used methods are SEM (~53%) and DLS (with 10%).
Figure 15. Determination methods used for characterizing the shape and size of aggregates.
28% of the applicants declared that the material they registered contained impurities. Figure 16 depicts the methods used for determining the impurities in these materials.
Figure 16. Determination methods of impurities of the registered materials.
Nearly 60% of the applicants registered the values of the mean specific areas of their materials, with 94% of them declaring that they used the BET (Brunauer–Xxxxxx–Teller), 1% calculated the mean specific surface area using TEM results and 5% used other methods.
2.3.4. Evaluation of the determination methods used in the NanoRegister.
Table 2 summarizes the different methods used for meeting the different parameters provided by the applicants in the complete registrations.
Size and shape | Impurities | Specific surface area | |
Constituent particles | Agglomerates/Aggregates | ||
TEM (34.2%) | SEM (53.3%) | HPLC (41.2%) | BET (94%) |
SEM (32.9%) | DLS (10%) | X-ray Fluorescence (17.6%) | Other (5%) |
Supplier Information (15.1%) | Static light scattering (8.3%) | GC (11.8%) | TEM/EM (1%) |
DLS (7.6%) | Laser Diffraction (5%) | ICP-OES (11.8%) | |
Turbidity and Interference Optics (3.4%) | Malvern Laser Particle analyzer (3.3%) | ICP-MS (2.9%) | |
No information available (2.7%) | Laser Diffraction dry powder system (3.3%) | Other (2.9%) | |
TEM and SEM (1.3%) | TEMAIA (3.3%) | X-ray Fluorescence and ICP-MS (2.9%) | |
SEM and DCS (1.3%) | XRDC (1.6%) | GC and Other (2.9%) | |
Centrifuge photosedimentometry (0.7%) | Laser Diffraction Particle Sizer (1.6%) | ICP-OES and ICP- MS (2.9%) | |
FESEM (0.7%) | Laser Scanning (1.6%) | ICP-OES and HPLC (2.9%) | |
Laser Scattering Malvern Instruments P2000 (1.6%) | |||
Malvern Instrument (1.6%) | |||
Microscopy (1.6%) | |||
MEB (1.6%) | |||
ATM (1.6%) |
More than 67% of the applicants used Electron Microscopy (EM) methods, and in particular TEM (34.2%) and SEM (32.9%), to determine the size and shape of the constituent particles and more than 53% of the applicants used Electron Microscopy (EM) methods to determine the size and shape of the aggregates.
TEM and SEM belong to the counting methods that allow for the determination of size and size distributions, as they measure the particle properties at the level of individual particles, and both use an electron beam for sample visualization down to the nm scale [7].
If done properly counting methods like TEM, SEM and AFM will result in a reliable number based distribution of the size of the constituent particles and they will allow identifying individual constituent particles and agglomerates/aggregates.
In very few cases measurement uncertainties and description of the parameters are reported (Figure 5), which makes assessment of the quality of the measurements difficult.
Dynamic Light Scattering (DLS) was also used for the size and shape determination of both constituent particles (7.6%) and aggregates (10%). DLS which belongs in the ensemble methods (all particles in the sample are measured at the same time and the size distribution is extracted from a combined signal from all particles), is a technique for characterization of colloidal systems based on the scattering of visible light resulting from the difference in refractive index between the dispersed colloids and the dispersion medium.
Ensemble methods, used in 1/3 of the applications based, on light scattering such as DLS, Static light scattering and Laser Diffraction (5%) do not allow to identify constituent particles in agglomerates and aggregates and they tend to give wrongly biased results in case of polydisperse size distributions. Estimation of the constituent particles sizes by these methods is often unreliable. This is elaborated in detail in Nanodefine Methods Manual JRC technical reports [7].
Many types of impurities can be expected depending on the type of the material. Therefore, for impurities detection in the materials several methods were used, including HPLC (41.2%), X-ray Fluorescence (17.6%), GC (11.8%) and ICP-OES (11.8%). These methods can analyze different types of impurities. The mean specific surface area was mostly calculating by the applicants (94%) by using the BET method. BET, is a standardized method [8] that specifies the determination of the overall specific external and internal surface area of disperse (e.g. nano-powders) or porous solids by measuring the amount of physically adsorbed gas according to the Xxxxxxxx, Xxxxxx and Xxxxxx (BET) method. It takes account of the International Union for Pure and Applied Chemistry (IUPAC) recommendations of 1984 and 1994.
The number of limited registrations for the trade year 2017 was 227, with 209 having a previous registration number and 18 not having one. According to the NanoRegister and as described in section 2.5, for the limited registrations the registrant could replace the physicochemical characteristics of the nanoparticulate state substance by entering the registration number of this previous registration. Therefore, for these registrations the physicochemical characteristics of the substances were only provided in pdf files from the previous registrations.
For these registrations using a previous registration number, it was checked whether the used "previous registration number" was valid and that it contained the data that also apply to the concerned registration
.
Note that for different limited registrations the same previous registration number was given multiple times (e.g. for the limited registrations BE-00097 and BE-000903 the same previous registration BE- 000091 was given). The 209 limited registrations were corresponding to 116 previous registrations. The files of these 116 registrations were downloaded and checked one by one. From them, 54 registrations were incomplete and the applicants declared that the results of the physicochemical characterization were pending, and for 14 registrations the applicants declared that they had already submitted the data in previous registrations.
The compliance check was therefore performed for the rest 48 limited registrations. The following physicochemical parameters that the applicants provided were checked: shape of the material and determination method of its size and shape, mean and median sizes of dimensions 1 and 2 their standard deviations, and the presence of answer for the existence of: agglomerates, aggregates, determination method of aggregates, coating, impurities, crystallographic phase, specific surface area, and surface charge. The results of the compliance check are presented in Figure 17 and Figure 18. As observed, in the 48 registrations, all applicants provided all the relevant information and the compliance for all parameters is 100%.
Additionally, for these 48 complete dossiers, it was evaluated per parameter whether the physicochemical data reported were in accordance with what is currently technically possible on the basis of literature data and of the results of research projects such as NanoDefine, NANoREG and To2DeNano projects and the data were analyzed statistically.
Figure 18. Compliance check for the limited registrations.
Most of the applicants (92%) used EM methods to characterize the size of the constituent particles. EM methods can give suitable constituent particles measurements, as previously discussed in paragraph
2.3.4 for the complete registrations.
For the size determination of the aggregates the applicants used mostly DLS, while in the complete registrations SEM was mostly employed method. Comparison of results obtained by different methods is very difficult: results of these methods based on different principles are method-dependent [7].
To conclude, the determination methods used for the size and shape of the constituent particles and agglomerates/aggregates in the limited registrations are similar with the ones of the complete registrations. Because results are method-dependant, only comparisons between results obtained by the same method are meaningful.
Only the substances used for commercial purposes are subjected to registration and are submitted by the Declarants who indicate the quantities that were placed on the BE market. The registrations of substances exclusively used for scientific purposes (simplified registrations) and the registrations submitted by the Foreign Supplier do not require indication of quantities.
For the trade year 2017, 777 registrations of quantity were submitted. The quantities could be registered as estimated or real quantities in kilograms. From there registrations, 558 are archived (Archivé, -72%), 168 are submitted (soumis, -22%) and 51 are drafts (brouillon, -6%).
From the 777 registrations, 353 registrations were mixtures (Enregistrement mélange) and simplified (Enregistrement simplifié) and no quantity was provided. From the rest 424 registrations of the substances, 13 registrations did not indicate quantities, 66 users introduced estimated quantities and 345 introduced real quantities.
The total quantity of substances produced in the nanoparticulate state, which was introduced on the Belgian market in 2017, as calculated from the 411 substance registrations, is 201429533.6 kg (201429.5336 tons) based on the recorded data with:
• 64042.51 tons imported and
• 137387.02 tons produced.
This section does not take into account the amount of substances that was distributed, since this is in fact a relocation of a product that is already on the Belgian market. Figure 20 shows the quantities of the substances containing nanomaterials registered during the trade year 2017. In most of the registrations (78%), the user declared quantities that range between 10 and 100000 kg. A significant percentage of about 46% (190 registrations) concerns quantities of less than 1 ton (109 of them are less than 100 kg) and therefore falls outside the scope of the REACH legislation.
Figure 20. Number of registrations per interval quantity imported or produced.
Table 3 gives the list of substances that were introduced on the Belgian market in a total quantity that is larger than 1000 tons. This amount refers to the sum of all registrations submitted under the specified generic name.
Table 3. Generic name of the nanomaterials that were produced and/or imported in quantities
>1000 tons in the trade year 2017.
Chemical Name of substance |
Iron hydroxide oxide yellow |
Calcium carbonate |
Diiron trioxide |
Calcium carbonate treated with stearic acid |
Silicon dioxide |
Carbon black |
During the registration of the substances in nanoparticulate state, the registrant could be assigned by different roles in the supply chain. Five choices in the NanoRegister platform give the possibility to the applicant to select his role. These choices include the “Distributor”, the “Importer”, the “Formulator”, the “Producer” and “Other”. Figure 21 shows the normalized quantity registered per role for the trade year 2017 and Figure 22 show the distribution of the quantities per role.
Figure 21. Quantity percentage registered from the different roles for the trade year 2017.
3. Suggestions and solutions
Based on the present analysis, several problems, indicated in bold were observed. We found solutions to deal with these problems, hereinafter indicated in blue color.
We propose adaptations, indicated in black, for the optimization of the NanoRegister and for future data collection.
i. Multiple registrations with the same number are present related to updates and adaptations of the data over time. We successfully wrote an algorithm that identifies the most recent registration automatically and allows to base the evaluation only on these recent registrations. Previous registrations of the same product/material were omitted from the new dataset. When multiple registrations for the same product/material were introduced on the same day, the registration with the most filled cells was kept. Even though this approach assumes that the registration with the most filled cells is the most complete, it addresses the problem having multiple registrations for the same product/material.
Because this is a complex solution, in the future the system should foresee a possibility to update the data without creating a new registration number.
ii. Overall the registrations were done in several languages making the comparison and statistics analysis difficult.
iii. For the same registration completed fields can be found both in French and English. For the present evaluation, the data were translated in English and introduced in a new database.
We suggest to adapt the user interface of the database such that only data in one language can be entered (preferably English) or to work with language independent codes.
iv. Within the same parameter the applicants utilized no harmonized wording. For the present evaluation the data entered in multiple terms will be grouped, when feasible, in English.
We suggest to adapt the user interface of the database for example by foreseeing obligatory drop lists, such that generally more harmonized wording is used.
v. Many of the required parameters leave room for interpretation by the applicants.
vi. Many measurands are asked for and for specific parameters very little information is provided. We analyzed all data but found out that measurands with a low number of entries make interpretation of statistical analysis problematic. An example is the surface charge where information is relevant only for dispersions. This can explain the limited data (5%) provided by the applicants for zeta potential, medium, pH value and ionic strength.
We propose to foresee these additional information conditionally, depending on the input values e.g. no requirements for zeta potential, medium, pH value and ionic strength for powders, only for dispersions.
i. There are no standardized descriptors for size and shape measurands.
ii. The input should be better defined. It cannot be determined whether the absence of information “-” means a negative answer or absence of answer.
iii. Applicants apply the input fields for parameters to ask specific questions to NanoRegister staff.
In the new database, we interpreted the data case by case and we formulated the input and wording, when possible.
We suggest to require standardized descriptors in obligatory drop lists.
iv. Because of missing metadata, for example medium of surface charge, the provided values cannot be interpreted. For example in the particle size and shape characteristics, the applicants are asked to describe the experimental circumstances of the used method and the motivation for the use of this method but the responses are not standardized.
v. Annexes are missing making interpretation of the provided information difficult (no metadata).
vi. It is impossible, also for experts, to interpret many of the inputs provided for many parameters e.g. 230 V for electron microscopy.
Because the predefined, method-specific metadata were not included or were difficult to access in the annexes, no detailed analysis was possible.
Support should be provided to the applicants directing them to international standards and guidelines (ISO, OECD, CEN). This foresee all requirements for metadata and reporting.
vii. For critical parameters, often no measurements uncertainties are provided.
We consider this a problem. It makes proper evaluation of the data difficult because variation is expected and is unknown.
Provision of measurements uncertainties should be obligatory for specific parameters, in line with international standards and guidelines (ISO, OECD, CEN).
viii. During registration applicants can provide CAS, EC and REACH registry numbers, however, no specific format is required to enter these numbers.
We could only do a compliance check and could not check if the input information was correct.
We propose to implement a strict input format in the NanoRegister so the applicants can avoid erroneous introduction of registry numbers. For instance a CAS registry number includes up to 10 digits which are separated into 3 groups by hyphens (xxxxxxx-yy-z).
ix. The characteristics dimensions that the applicants are asked to provide are not always optimal and adapted to the applied methodology.
Only a compliance check could be done.
The requested parameters should be revisited and adapted in line with the guidelines in the Nanodefine Methods Manual [7].
x. The NanoRegister assumes that the applicants can distinguish the aggregates from agglomerates.
There are no standardized methods to distinguish the agglomerates from aggregates yet. We suggest not to make a distinction between agglomerates and aggregates for any of the parameters requested.
This project evaluates the registration of materials produced in a nanoparticulate state according to the KB of May 27th 2014. The Royal Decree concerning the placing on the market of substances manufactured in nanoparticulate state was signed on May 27th, 2014, published on September 24th, 2014, and modified on December 22nd, 2017. According to this Royal Decree, the deadlines for registration of substances and mixtures manufactured in a nanoparticulate state were January 1st, 2016 and January 1st, 2018, respectively. The registration software was launched on September 15th, 2015. Phase 1 of the project included the evaluation of the registrations of the trade year 2017 and was successfully completed and reported in this document. As a next step, data extraction and statistical analysis methods will be applied to evaluate the registrations of the trade year 2018.
For 2017, the completion of obligatory fields within the registration dossiers (“compliance check”) and the quality of the content of the submitted dossiers were assessed.
The compliance check assessed for each dossier if all obligatory fields were completed by the applicants. For the simplified registrations it was checked if the declaration of honour was added to the dossier. A derived, “compliance” database was constructed and a statistical analysis of the data in the “compliance“ database was done.
The content of the register was evaluated per parameter, and included listing and evaluating the methods used for measuring each registered parameter, and the number of different materials and their quantity. For the complete dossiers, it was assessed per parameter if the reported physicochemical data are in accordance with the current technical possibilities.
The results of the assessment and a list of recommendations for further optimization of the register based on this assessment are reported in this document.
The main results for the trade year 2017 are summarized as:
• During the trade year 2017, 454 registrations were submitted.
• Evaluation of the submitted registrations showed that most of the applicants provided the requested information for the materials they registered, and the declaration of honor for the simplified registrations was undersigned (100%).
• In the complete registrations, most of the obligatory information was present, as indicated from the compliance check, although specific parameters, as for instance the uncertainties of size measurements, were systematically missing (15%).
• In 92% of the limited registrations the applicants provided the previous registration numbers and the compliance check revealed that the physicochemical characteristics of the substances were present (100%).
• In total 179 different materials (chemical substances) were identified that are presented in the Annex. The chemical identification makes no distinction between the possible differences in the physicochemical properties of these substances.
• Evaluation of the determination methods (complete registrations) used to characterize the physicochemical characteristics of the nanoparticulate materials showed that the applicants employed well established methods, such as EM (67%) for the characterization of the constituent particle size and BET (94%) for the calculation of the mean specific surface area.
• The total quantity of substances in the nanoparticulate state, which was introduced on the Belgian market in 2017 was 201429533.6 kg (201429.5336 tons) based on the recorded data.
• The substances that were introduced on the Belgian market in a total quantity that is larger than 1000 tons are iron hydroxide oxide yellow, calcium carbonate, diiron trioxide, calcium carbonate treated with stearic acid, silicon dioxide and carbon black. In most of the registrations (78%), the applicants declared quantities that range between 10 and 100000 kg.
• About 46% (190 registrations) of the submitted registrations reported quantities below 1 ton and would therefore be considered to be out of the scope of the REACH-regulation.
REFERENCES
[1] “27 MAI 2014. — Arrêté royal relatif à la mise sur le marché des substances manufacturées à l’état nanoparticulaire, p. 76184.” [Online]. Available: xxxxx://xxx.xxxxxx.xxxxxxx.xx/xx/xxxx/00000.
[2] Service public fédéral Santé publique, Sécurité de la Chaîne alimentaire et Environnement, “De registratie van stoffen geproduceerd in nanoparticulaire toestand KB 27 mei 2014.” Service public fédéral Santé publique, Sécurité de la Chaîne alimentaire et Environnement, 2018, Accessed: Jan. 13, 2020. [Online]. Available: xxxxx://xxx.xxxxxx.xxxxxxx.xx/xx/xxxx-xxxxxxxxxxx-xxxxxxxxxxxx- 2016.
[3] “Commission Recommendation of 18 October 2011 on the definition of nanomaterial (2011/696/EU),” Official Journal of the European Communities: Legis, 2011.
[4] Xxxx Xxxxx-xx-Xxxxxx et al., “Automatic morphological categorisation of carbon black nano- aggregates,” presented at the Proceedings of the 21st international conference on Database and expert systems applications: Part II, Bilbao, Spain, 2010.
[5] X. X. Xxxxxxxx and L. L. Xxxxx, Stratigraphy and sedimentation. San Francisco: X. X. Xxxxxxx, 1963.
[6] X. Xxxxx-Xxxxxx, X. Xxxxxx, X. X. Xxxxxx, and X. Xxxxx, “Towards the taxonomic categorization and recognition of nanoparticle shapes,” Nanomedicine, vol. 11, no. 2, pp. 457–65, Feb. 2015, doi: 10.1016/j.nano.2014.07.006 S1549-9634(14)00416-X [pii].
[7] X. Xxxx et al., “The NanoDefine Methods Manual. Part 1,2,3,” Publications Office of the European Union, 2020. Accessed: Apr. 30, 2020. [Online]. Available: xxxxx://xxxxxxxxxxxx.xxx.xx.xxxxxx.xx/xxxxxxxxxx/xxxxxx/XXX000000.
[8] X. X. Xxxxxxxx et al., “Determination of particle size, surface area, and shape of supplementary cementitious materials by different techniques,” Mater Struct, vol. 48, no. 11, pp. 3687–3701, Nov. 2015, doi: 10.1617/s11527-014-0431-3.
ANNEX
List of the names of the chemical substances registered during the trade year 2017.
Chemical Name of substance |
[1,3-dihydroxy-5,6-bis[[(2-hydroxy-1-naphthalenyl)-metylene]amino]2H-Benzimidazole-2-onato(2-N5,N6,O5,O6-nickel |
29H,31H-phthalocyanine |
(3-carboxy-1,1'-(1,2-dicyanovinylenebis(nitrilomethylidyne)-2,2'-dinaphtholato)nickel(II) |
(PLC) 2-Propenoic acid, 2-methyl-, polymers with Bu acrylate, Et acrylate, Memethacrylate and polyethylene glycol methacrylate C16-1 |
1,4,5,6-tetrachloro-N-[2-(4,5,6,7-tetrachloro-2,3-dihydro-1,3-dioxo-1H-inden-2-yl)-8-quinolyl]phthalimide |
1,4-bis(butylamino)anthracene-9,10-dione |
1,4-bis(mesitylamino)anthraquinone |
1,4-Bis(p-tolylamino)anthraquinone |
12H-Phthaloperin-12-one |
14H-Anthra(2,1,9-mna)thioxanthen-14-one |
14H-benz[4,5]isoquino[2,1-a]perimidin-14-one |
2-(3-hydroxy-2-quinolyl)-1H-indene-1,3(2H)-dione |
2-(3-Oxobenzo[b]thien-2(3H)-ylidene)-benzo[b]thiophene-3(2H)-one |
2,2'-(1,4-phenylene)bis[4-[(4-methoxyphenyl)methylene]oxazol-5(4H)-one] |
2,2'-[(2,2',5,5'-tetrachloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] |
2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] |
2,2'-[ethylenebis(oxyphenyl-2,1-eneazo)]bis[N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide |
2,9-Bis[4-(phenylazo)phenyl]anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone |
2,9-Dimethylanthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone |
2-[(4-chloro-2-nitrophenyl)azo]-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide |
2-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azo]benzoic acid |
29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper |
2-octadecyl-1H-benzo[3,4]isothiochromeno[7,8,1-def]isoquinoline-1,3(2H)-dione |
2-Propenoic acid, 2-methyl-, methyl ester, polymer with butyl 2-propenoate and ethenylbenzene |
2-Propenoic acid, 2-methyl-, polymer with ethane |
3,3'-[#9,10-dihydro-9,10-dioxo-1,4-anthrylene#diimino]bis[N-cyclohexyl-2,4,6-trimethylbenzenesulphonamide] |
3,3'-[(2-chloro-5-methyl-p-phenylene)bis[imino(1-acetyl-2-oxoethylene)azo]]bis[4-chloro-N-(3-chloro-o-tolyl)benzamide] |
3,3'-[(2-Methyl-1,3-phenylene)diimino]bis[4,5,6,7-tetrachloro-1H-isoindol-1-one] |
3,4,5,6-Tetrachloro-N-[2-(4,5,6,7-tetrachloro-2,3-dihydro-1,3-dioxo-1H-inden-2-yl)-8-quinolyl]phthalimide |
3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo(3,4-C)pyrrole-1,4-dione |
3,6-bis(4-chlorophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrol-1,4-dione |
4,4'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[2,4-dihydro-5-methyl-2-(p-tolyl)-3H-pyrazol-3-one] |
4,4'-diamino[1,1'-bianthracene]-9,9',10,10'-tetraone |
4,4'-methylylidenebis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one) |
4,5,6,7-Tetrachloro-3-[[3-methyl-4-[[4-[(4,5,6,7-tetrachloro-1-oxo-1H-isoindol-3-yl)amino]phenyl]azo]phenyl]amino]-1H- isoindol-1 |
4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide |
5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione |
5,12-dihydroquino[2,3-b]acridine-7,14-dione |
5,5'-(1H-isoindole-1,3(2H)-diylidene)dibarbituric acid |
6,15-dihydroanthrazine-5,9,14,18-tetrone |
8,18-dichloro-5,15-diethyl-5,15-dihydrodiindolo[3,2-b:3',2'-m]triphenodioxazine |
8,9,10,12-tetrahydro-6H-benzo[lm]diimidazo[4,5-c:1',2'-f]phenanthridine-7,11-dione |
AEROSIL 380 |
AEROSIL R202 |
AEROSIL R816 |
AEROXIDE ALU C |
Aluminium oxide |
Amorphous cera |
Amorphous silica |
Amorphous sodium aluminium silicate |
AZOMETHINE-COPPER COMPLEX |
Benzamide, 3,3'-[(2-chloro-1,4-phenylene)bis[imino(1-acetyl-2-oxo-2,1-ethanediyl)azo]]bis[4-methyl- |
BENZIMIDAZOLONE YELLOW |
C.I. Pigment Blue 1 |
C.I. Pigment Blue 62 |
C.I. Pigment Orange 13 |
C.I. Pigment Orange 34 |
C.I. Pigment Orange 64 |
C.I. Pigment Red 101 |
C.I. Pigment Red 122 |
C.I. Pigment Red 146 |
C.I. Pigment Red 170 |
C.I. Pigment Red 176 |
C.I. Pigment Red 177 |
C.I. Pigment Red 184 |
C.I. Pigment Red 2 |
C.I. Pigment Red 48:1 |
C.I. Pigment Red 48:2 |
C.I. Pigment Red 48:3 |
C.I. Pigment Red 48:4 |
C.I. Pigment Red 81:5 |
C.I. Pigment Violet 19 |
C.I. Pigment Violet 23 |
C.I. Pigment Violet 3 |
C.I. Pigment Violet 3:4 |
C.I. Pigment Yellow 110 |
C.I. Pigment Yellow 13 |
C.I. Pigment Yellow 138 |
C.I. Pigment Yellow 14 |
C.I. Pigment Yellow 150 |
C.I. Pigment Yellow 155 |
C.I. Pigment Yellow 181 |
C.I. Pigment Yellow 73 |
C.I. Pigment Yellow 74 |
C.I. Pigment Yellow 81 |
C.I. Pigment Yellow 83 |
Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate |
Calcium carbonate |
Calcium Carbonate treated with Stearic Acid |
Calcium hydrogen phosphate |
Carbon Black |
Carbon Black PowCarbon B |
Carbonic acid, zinc salt, basic |
Cerium Iron Oxyde Isostearate |
Cerium oxide isostearate |
Chromate(1-), bis(2,4-dihydro-4-(2-(2-(hydroxy-kappaO)-5-nitrophenyl)diazenyl-kappaN1)-5-methyl-2-phenyl-3H-pyrazol-3- onato(2-)-kappaO3)-, sodium (1:1) |
Chromium iron oxide |
Cobalt chromite blue green spinel |
Copolymère de Chlorure de Vinylidene |
Diiron trioxide |
Dimethyl 2-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azo]terephthalate |
Dimethyldichlorosilane reaction with Silica |
Dioxyde de silicium (silice amorphe synthétique) |
Ethanaminium, N,N,N-trimethyl-2-[(2-methyl-1-oxo-2-propenyl)oxy]-, chloride, homopolymer |
Ether, homopolymer, oxidized |
Fatty acids, montan-wax, ethylene esters |
Fumed metal oxide – Titaandioxyde |
Fumed silica |
Heucosin Special Grey |
Hexamethyldisilazane reaction with Silica |
Hydrated, Amorphous Silica |
Hydrogen [[[(2-ethylhexyl)amino]sulphonyl][[(3-methoxypropyl)amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)- N29,N30,N31,N32]cuprate(1-), compound with N,N'-di#o-tolyl#guanidine #1:1# |
Hydrogen bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-), compound with 2- ethylhexylamine (1:1) |
Hydrogen hydroxy[2-hydroxy-3-[(2-hydroxy-3-nitrobenzylidene) amino]-5-nitrobenzenesulphonato(3-)]chromate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1) |
Hydrophilic fumed silica |
Hydroxyde d'aluminium |
Indium tin oxide |
Iron hydroxide oxide yellow |
Iron oxide isostearate |
ISOINDOLINONE PIGMENT |
ITO |
Magnesium silicate |
Methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate |
Methyl-alkenoic (C=3-6) acid, polymers with alkyl(C=1-4) acrylate, polyalkylene glycol methacrylate alkyl ethers and polyalkylenepolyalkylene( C=2-4) glycol methacrylate (disubstitutedcarbopolycyclic) ethyl ether |
N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-2-[(4-nitrophenyl)azo]-3-oxobutyramide |
N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxo-2-[[2-(trifluoromethyl)phenyl]azo]butyramide |
N,N'-(2,5-Dichloro-1,4-phenylene)bis(4-((2,5-dichlorophenyl)azo)-3-hydroxynaphthalene-2-carboxamide) |
N,N'-(2,5-dichloro-1,4-phenylene)bis[4-[[2-chloro-5-(trifluoromethyl)phenyl]azo]-3-hydroxynaphthalene-2-carboxamide] |
N,N'-naphthalene-1,5-diylbis[4-[(2,3-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide] |
N,N'-Phenylene-1,4-bis[4-[(2,5-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide] |
N-[4-(aminocarbonyl)phenyl]-4-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azo]benzamide |
Oxirane 2-[[3-(triethoxysilyl)propoxy]methyl]-hydrolisis product with silica |
Pigment Blue 15.3 |
Pigment Blue 15:1 |
Pigment Brown 23 |
Pigment Brown 43 |
Pigment Red 101 |
Pigment Red 101 |
Pigment Red 254 |
Pigment Violet 19 |
Pigment Yellow 110 |
Pigment Yellow 128 |
Pigment Yellow 138 |
Pigment Yellow 42 |
Pigment Yellow 93 |
Polyvinylchloride |
Precipited calcium carbonate |
Printex, Lamp black, Colour Black, XPB, Special Black |
Pyrogenic colloidal silica |
Pyrrolo[3,4-c]pyrrole-1,4-dione, 3,6-bis([1,1'-biphenyl]-4-yl)-2,5-dihydro- |
Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, salts with bentonite |
QUINOPHTHALONE YELLOW PIGMENT |
Reaction mass of nickel, 5,5'-azobis-2,4,6(1H,3H,5H)-pyrimidinetrione complexes and melamine |
Short tangled multi-wall carbon nanotubes obtained by catalytical chemical vapour deposition |
Silane, dichlorodimethyl-, reaction products with silica |
Silic acid lithium magnesium sodium salt |
Silica gel, precipitated, crystalline free |
Silica, [(trimethylsilyl)oxy]-modified |
Silica, Amorphous |
Silica, amorphous, fumed, crystalline free |
SILICE PYROGENEE AMORPHE |
Silice synthétique amorphe |
silicic acid, calcium salt (synthetic amorphous calcium silicate) |
Silicic acid, lithium magnesium sodium salt |
Silicic acid, magnesium salt |
Silicium dioxide |
Silicones and siloxanes, dimethyl-, reaction products with silica |
Sodium Bicarbonate |
Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-) |
Sodium magnesium aluminium silicate |
Surface treated silica |
Synthetic amorphous magnesium silicate |
Synthetic amorphous silica |
Synthetic amourphous silica-Gasil |
TETRACHLOROISOINDOLINONE YELLOW |
Setramethyl 2,2'-[1,4-phenylenebis[imino(1-acetyl-2-oxoethane-1,2-diyl)azo]]bisterephthalate |
Titanium dioxide |
Trans- Oxide AC0500 |
Zinc Oxide |
CONTACT
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