Program PARTENERIATE - PNII-PT-PCCA-2011-3.2-0979 Contract nr. 164/2012
Autoritate contractanta:
Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii Dezvoltarii si Inovarii
Contractor principal: Institutul de Xxxxxx Xxxxxxxxxxxxxxx “Xxxxx Xxxx" Iasi
BIONANOMED
Program PARTENERIATE - PNII-PT-PCCA-2011-3.2-0979
Contract nr. 164/2012
Domeniul: Materiale, procese si produse inovative
Durata proiect: 2012 - 2015
CONSORTIU
Coordonator proiect:
INSTITUTUL DE CHIMIE MACROMOLECULARA “XXXXX XXXX” IASI
Director proiect: Xx. Xxxxxxxx Xxxxxx
Partener P1: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU STIINTE BIOLOGICE BUCURESTI (INCDSB)
Director proiect P1: Xx. Xxxxxx Xxxxx
Partener P2:
S.C. I.C.P.E. BISTRITA
S.A. (ICPE) Director proiect P2: Dr. Xxxxx Xxxx
▪ Obtinerea unei noi categorii de materiale – BIONANOCOMPOZITE continand amestecuri de polimeri sintetici cu polimeri naturali, optimizate cu nanoparticule de argint cu efect antimicrobian.
▪ Stabilirea unor tehnologii de prelucrare a acestor materiale in vederea obtinerii unor dispozitive medicale cu proprietati speciale, biocompatibile, biodegradabile, antimicrobiene.
• bioactivarea unor polimeri sintetici biodegradabili nou sintetizati (PLA, PVA, PU) modificati cu polimeri naturali in vederea cresterii biocompatibilitatii;
• obtinerea de nanoparticule de argint cu dimensiuni controlate;
• optimizarea bionanocompozitelor polimerice obtinute prin imprimarea de proprietati antimicrobiene;
• caracterizarea fizico-chimica si biologica a bionanocompozitelor obtinute in vederea stabilirii domeniului lor de utilizare;
• elaborarea unei tehnologii de obtinere a unui dispozitiv medical biodegradabil cu proprietati antimicrobiene
Valoare de la buget (lei) | Cofinantare proprie (lei) | |
Etapa 2012 | 254 000 | 0 |
Etapa 2013 | 815 100 | 62 103 |
Etapa 2014 | 918 800 | 70 497 |
Etapa 2015 | 324 600 | 54 900 |
Total | 2 312 500 | 187 500 |
Total proiect | 2 500 000 | |
ETAPA I (26.07.2012 – 10.12.2012):
Stabilirea/selectarea conditiilor din punct de vedere stiintific si tehnic pentru obtinerea unor materiale cu proprietati antimicrobiene.
Obiective:
▪ Realizarea unui studiu privind obtinerea dispozitivelor medicale biodegradabile si antimicrobiene
Diseminarea rezultatelor: Etapa 2012
Comunicari
2eme Colloque Franco-Roumain de Chimie Medicinale, Iasi, 3 – 5 Octombrie 2012,Iaşi
1. In vivo and in vitro sustained release study of theophylline from biodegradable and biocompatible alginate/PNIPAAm hydrogels, R. P. Dumitriu, A.M. Oprea, C. N. Xxxxxxxx, X. Xxxxx, C. M. Xxxxxxx, X. Xxxxxxx, X. Xxxxxx
2. Anhydride-modified collagen, X.Xxxxxx, X.Xxxxxx, X.Xxxxxxxxx, X.X Xxxxxx
Zilele Universității ”Al. X. Xxxx”, Conferința Facultății de Chimie, Iași, România, 25-27 Octombrie (2012).
3. (Bio)active Layers Deposition by Electrospraying, X. Xxxxxxx, B. S. Xxxxxxxx, X. Xxxxxxx, X.
X. Xxxxxx M. C. Xxxxxx, X. Xxxxxx.
4. Electrospun coatings for antioxidant food packaging, R.P. Xxxxxxxx, X.X. Xxxxxxxx, F. J. Xxxxx,
X. Xxxxxx
5. Hydrolytic degradation of some poly(vinyl alcohol) copolymers for biomedical applications,
R. Lipsa, X. Xxxxxxxxx, X. Xxxxxx, X. X. Xxxxxx, X.Xxxxxxxx
COST Action FA0904 International Workshop , “Processing technology and functional properties of polymer nanomaterials for food packaging”, Wroclaw, Poland Sept 11-12, 2012
1. Electrospraying of the Chitosan/Vitamin E Formulations onto Various Substrates, B. S. Xxxxxxxx, X. Xxxxxxx, X. Xxxxxx, M. C. Xxxxxx, X. Xxxxxx
Zilele Universității ”Al. X. Xxxx”, Conferința Facultății de Chimie, Iași, România, 25-27 Octombrie (2012).
2.Testing of antioxidative and antimicrobial activity of some new food packagings, X. Xxxxxxx,
X. Xxxxxx, R.N. Darie, X. Xxxxxxx, B.S. Munteanu.
3. Gas permeability of some biocomposites; X. Xxxxxxx, X.X. Xxxxx, A. Xxxxxxxxxxxx, X. Xxxxxx
NanoTech Italy 2012 International showcase for nanotechnologies, Workshop COST Action: FA0904, Safety, Ethics and Societal Impact Venetia, Italia, 23 noiembrie 2012.
4. Toxicity, biocompatibility and degradability of some modified natural polymers used for food packaging, R.P. Dumitriu, A.M. Oprea, X. Xxxxxx
ETAPA II (11.12.2012 – 10.11.2013):
Obtinerea unor nanocompozite polimerice biocompatibile si biodegradabile cu proprietati antimicrobiene
Obiective
-Sinteza si caracterizarea unor polimeri biodegradabili comerciali si sintetizati in laborator: alcool polivinilic (PVA), poliuretan (PU) si acid polilactic (PLA)
-Prepararea unor materiale bionanocompozite pe baza polimerilor obtinuti si a unor biopolimeri naturali: colagen, elastina, condroitin sulfat, acid hialuronic
- Obtinerea de nanoparticole de argint prin metoda electrolizei cu electrozi de argint precum si prin metoda electrospinning
-Studiul interactiunii dintre amestecurile bioactive si nanoparticule in scopul obtinerii unor materiale cu proprietati antimicrobiene
--Evaluarea caracteristicilor fizico-chimice ale bionanocompozitelor bioactive si antimicrobiene obtinute
-Evaluarea in vitro a biocompatibilitatii materialelor prin determinari fizico chimice
(conform Farmacopeei Europene in vigoare) si biologice prin determinarea citotoxicitatii
Rezultatele stiintifice obtinute
• S-au preparat si caracterizat bionanocompozite si componentii lor:
– S-a perfectionat instalatia de “electrospinning” si s-au obtinut nanoparticule de Ag (AgNP), Ag/chitosan
– Poliuretan/biopolimeri/nanoparticule de argint prin incorporare sau prin depunere
– Acid polilactic/nanoparticule de argint/Vitamina E; acid polilactic/chitosan si acid polilactic/chitosan/ (AgNP),
– Poli(vinil alcool)/chitosan
Caracterizarea s-a efectuat prin spectroscopie UV, FT-IR, reologie, SEM, AFM, XDR, studiul proprietatilor mecanice si termice, permeabilitate la gaze, proprietati antioxidante, titrari potentiometrice,
– S-a realizat unele teste microbiologice, activitate antimicrobiana si antioxidanta
Diseminarea rezultatelor: Etapa 2013
Publicatii:
1. Preparation of medical devices with antimicrobial properties, M. Râpă, X. Xxxxxx, E. E. Tănase, X. Xxxxx, X. Xxxx, Journal of Optoelectronics and Advanced Materials Vol. 15, No. 7- 8, July – August 2013, P. 807 – 816;
2. Novel Environmentally Friendly Copolymers Carboxymethyl Starch Grafted Poly(Lactic Acid) Rodica Lipsa. Xxxx Xxxxxxxxx, Xxxxxxxx Xxxxxx, Xxxxxx Xxxxxxx, Xxxx Xxxxxxxx, X Xxxxx Xxxxxxx (2013) 21:461–471;
3. Evaluation of the Controlled Release Ability of Theophylline from Xanthan/Chondroitin Sulfate Hydrogels. Xxx-Xxxxx Xxxxx, Xxxxxxx-Xxxxxxx Xxxxxx, Xxxxxx Xxxxx Xxxx, Xxxxxxxx Xxxxx Xxxxxxxx, Xxxxxxxx Xxxxxx Journal of Biomaterials and Nanobiotechnology, 2013, 4, ***-*** Published Online April 2013 (xxxx://xxx.xxxxx.xxx/xxxxxxx/xxxx)
4.Lignin Modification with Carboxylic Acids and Butyrolactone under Cold Plasma Conditions, Xxxx Xxxxxxx, Xxxxxx Xxxxxxx, Xxxxxxxx Xxxxxx, Xxxxxx Xxxxxxxx, and Xxxxxxxx Xxxxxx, xx.xxx.xxx/00.0000/xx0000000, Ind. Eng. Chem. Res. 52, 13264–13271 (2013)
xx.xxx.xxx/00.0000/xx0000000.
5.Chitosan coatings applied to polyethylene surface to obtain food-packaging materials. Xxxxxxxx Xxxxxxxxx Xxxxxxxx, Xxxxx Xxxxxxx, Xxxxxx Xxxx Xxxxxxx, Xxxxxxxx Xxxxxxx, Xxxx Xxxxxxx Xxxxxxx, Xxxxxxxx Xxxxxx, Xxxx. Chem.
Technol. 48 (5-6), 565-575 (2014);
6. Effectiveness of chitosan as antimicrobial agent in LDPE/CS composite films as poultry minced meat packaging materials, X. Xxxxxx, X.X. Xxxxx, X. Xxxxxxx, X. Xxxxxxx, A. Xxxxxxxxxxxx, X. Xxxxxxx, S.B. Xxxxxxxx, X. Zuburtikudis, Cell. Chem. Technol 48 (3-4), 325-336 (2014);
• COST ACTION FA0904 “Eco-sustainable Food Packagingbased on Polymer Nanomaterials” INTERNATIONAL WORKSHOP: Characterization, Mechanics and Performance of Innovative Polymer Nanomaterials for Food Packaging Application 24-25 September 2013, Varna, Bulgaria. Xxxxxxxx Xxxxxx-Xxxxx” Hotel Congress Complex, “Sts. Xxxxxxxxxxx and Xxxxxx”, Varna
1. Poly(vinyl alcohol) composites and nanocomposites for food packaging. X. Xxxxxx, X. Xxxxxxxxx X. Xxxxxx;
2. Characterization by AFM and nano-indentation method of some stratified nanocomposites destined to food packaging. X. Xxxxxxx,X. Xxxxxx,X. Xxxxxxxx, X. Xxxxxxxxxx, X. Xxxxxx
3. New potential applications in food packaging of the electrospinning / electrospraying method used for polymer surface modification and to obtain of nano(micro)structures from antimicrobial agents as chitosan, silver and various bioactive agents. I. Polylactic acid / Silver NP/Vitamin E bio- nanocomposite fibers with antibacterial and antioxidant activity. X. Xxxxxxxx, X. Xxxxx, X. Xxxx, X. Xxxxxx.
10th International Conference on Nanosciences & Nanotechnologies (NN13) 9-12 July 2013, Thessaloniki, Greece
1. Poly(vinylalcohol)/chitosan/montmorillonite hydrogel nanocomposites, Xxxxx Xxxxxxxxx, Xxxxxxxx Xxxxxxxx Xxxxxx, Xxxxxxx-Xxxxxxx Xxxxxx, Xxxxxxxx Xxxxxx
2. Polyethylene/ chitosan-Na+-MMT nanocomposites, R.N. Darie, X. Xxxxxxx, X. Xxxxxxx, A. Xxxxxxxxxxxx, X. Xxxxxxxxxx, X. Xxxxxxxxxxxx, X. Fras, X. Xxxxxx, X. Xxxxxx
Al XI-lea Simpozion Internaţional de Produse Cosmetice şi Aromatizante, Iaşi – Romania, 4 – 7 Iunie 2013
3.“Textile de uz cosmetic cu caracter antioxidant”, Xxxxxxxx Xxxxxxx, Xxxxxx Xxxxxxx, Xxxxxxxx Xxxxxx Xxxxxxx Xxxxxxxx, Xxxxxx X. Xxxxxxx, Xxxxxx Xxxxxxxx
4. Biomateriale pe baza de nanocompozite alcool polivinilic/chitosan / montmorillonit preparate prin metoda inghet dezghet X. Xxxxxxxxx, C. Xxxxxxxx Xxxxxx, X.-X. Xxxxxxxx, X. Xxxxxx
• Zilele Academice Iesene, A XXIV-a Sesiune de Comunicari Stiintifice s Institutului De Chimie Macromoleculara „Xxxxx Xxxx” Iasi:Progrese în Stiinta Compusilor Organici și Macromoleculari Iasi, 3 - 5 Octombrie 2013
• 5. Caracterizarea Termica a Retelelor Semiinterpenetrate Pe Baza De Colagen Si 2- Hidroxietil Metacrilat X. Xxxxxx, X. Xxxxxx, X. Xxxxxx.
• 6. Depunerea de Formulari Biocompatibile pe Substrat Poliuretanic prin Electrospraying / Electrospinning. B. S. Xxxxxxxx, X. Xxxxxxxxxxx, X. Xxxxxxx, X. Xxxxxx, X. Xxxxxxxx, X. Xxxxxx
• 7. Activarea cu Enzime pentru Obtinerea de Materiale Textile Inteligente. X. Xxxxxxx, X.Xxxxxxx, X. Xxxxxxxx, X. Xxxxxx.
• 8. Imobilizarea Imunoglobulinei G si a Fibrinogenului pe Suprafata Poli(Fluorurii de Viniliden) X. Xxxxxxx, X. X. Xxxxxx, M. C. Xxxxxx, X. Xxxxxxx, X. Xxxxxx, X. Xxxxxx.
The 8th International Conference on Materials Science & Engineering – BraMat 2013, BRASOV, 28 Febr.-2 March 2013
1. Preparation of medical devices with antimicrobial properties. M. Râpă, X. Xxxxxx,X. Xxxxxx, X. Xxxxx,
X. Xxxx
International Workshop Waedenswil, Switzerland, March 21-22, 2013 COST FA0904:Eco-sustainable food packaging based on polymer nanomaterials: “Development of new safe PNFP and Development of strategies to identify any critical interaction of PNFP with food”
2. Polyethylene - chitosan composites and nanocomposites for food packaging X. Xxxxxx, X. Xxxxx, X. Xxxxxxx, X. Xxxxxxxx-Xxxxxx,
I. Zuburtikudis, Baklavaridis A.,G-M.Pricope.
10th International Conference on Nanosciences & Nanotechnologies (NN13) 9-12 July 2013, Thessaloniki, Greece
3. Hybrid collagen-based hydrogels with embedded montmorillonite nanoparticles X.X. Xxxxxx, X. Xxxxxx, X.X. Xxxxxxx
4. Biocompatibility, biodegradability and drug carrier ability of the hybrid collagen-based hydrogel nanocomposites. X. X. Xxxxxx, X. Xxxxxx, X. X.Xxxxxxx, X. Xxxxxx;
5. Effect of nanoclay hydrophibicity on the PLA/clay nanocomposites properties. Xxxxxxx, X. Xxxxx, X. Xxxxxxx, X. Xxxxxxxxxxxx, R.P. Xxxxxxxx, X. Xxxxxxxxxx, X. Zuburtikudis A., X. Xxxxxx
Salonul Naţional de Inventică CHIM - INVENT 2013, Iaşi – Romania, 3 – 5 iulie 2013
6. Obţinerea fibrelor textile receptive la modificări de temperatură şi pH, X. Xxxxxxx, X.X. Xxxxxx, X. Xxxxxx, a primit diploma si medalia “Xxxxx Xxxx” iar X. Xxxxxxx a primit diploma si cupa “Tanarul cercetator”.
7. Procedeu de obtinere a unui hidrogel bicomponent , R.P. Xxxxxxxx, X. Xxxxxx, a primit diploma si medalia “Xxxxx Xxxx”.
• Zilele Academice Iesene, A XXIV-a Sesiune de Comunicari Stiintifice s Institutului De Chimie Macromoleculara „Xxxxx Xxxx” Iasi:Progrese în Stiinta Compusilor Organici și Macromoleculari Iasi, 3 - 5 Octombrie 2013
• 8. Evaluarea Eficientei Analgezice A Ketoprofenului Încorporat in Hidrogeluri de Poli(N-Izopropilacrilamida) / Alginat de Sodiu. X. Xxxxxxx, X- X. Xxxxxxxx, X.Xxxxxx;
• 9. Membrane Biocompatibile de Baza de Poliuretan Continând Diferiti Compusi Naturali si Nanoparticule de Argint.
X. Xxxxxxx, X. Xxxxxxxxxxx, X. Xxxxx, X. Xxxxxxx, S. B. Xxxxxxxx, X. Xxxxx, X.Xxxxxxxxxx, X. Xxxxxxx, X. Xxxxxx.
Diseminarea rezultatelor: Etapa 2014
Publicatii:
1. Effect of Nanoclay Hydrophilicity on the PLA/Clay Nanocomposites Properties, R.N. Darie, X. Xxxxxxx, X. Xxxxxxx, G. M. Pricope, X. X.Xxxxxx, X. Xxxxxx, X. Xxxxxxxxxxxx, X. Xxxxxxxxxxxx, X.Xxxxxx, Industrial & Engineering Chemistry Research, 53 (19), 7877–7890 (2014).
2. Poly(lactic acid) co-Aspartic acid copolymers, Possible utilization in drug delivery systems, Xxxxxxxxx X., Xxxxx R., Xxxxxx X., X. Xxxxxxx, X. Polym. Env., 21:1064–1071 (2013).
3. Biocompatible and biodegradable alginate/poly(N-isopropylacrylamide) hydrogels for sustained theophylline release, R. P.Xxxxxxxx, X.-X. Xxxxx, C.N. Xxxxxxxx, X.-X. Xxxxxx, X. Xxxxx, X. X. Xxxxxxxx, X. Xxxxxxx, X.Xxxxxx, X. Appl. Polym. Sci., 131, 17, 2014;
4. Polylactic acid (PLA)/Silver-NP/VitaminE bionanocomposite electrospun nanofibers with antibacterial and antioxidant activity, B. S. Xxxxxxxx, X. Xxxxx, X.X. Pricope, X.Xxxx, X. Xxxxxx,
J. Nanoparticle Research, in press
5. Polyurethane-extracellular matrix silver bionanocomposites for urinary catheters, X.Xxxxxxxxxxx, X.Xxxxx, X. Xxxxxxx, B. S. Xxxxxxxx, X. X. Xxxxxxxx, X. X. Pricope, X. Xxxxxx, X. Xxxxxxxx, X. Xxxx and X.Xxxxxx, X. Bioact. Compat. Polym. accepted
6. Polyurethane biocompatible silver bionanocomposites for biomedical applications.
X. Xxxxx, X. Xxxxxxxxxxx, X. Xxxxxxx, B. S. Xxxxxxxx, X. X. Xxxxxxxx, X. Xxxxx and X.Xxxxxx X. Nanoparticle Research, accepted
1. Drug delivery and Release from polymeric nanomaterials, X. Xxxxxx, X.X. Xxxxx, X.X. Xxxxxx, A.M. Cojocariu, Chap. 2 in Nanotechnology and Drug Delivery, Ed. X.X. Xxxxx, CRC Press, p. 28-81.
2. Chapter 16 in Biocomposites: Design and Mechanical Performance: Polyolefin / Biomass Composites, X. Xxxxxx, X. X. Xxxxx, X. Xxxxxxxxx, Xxxxxxxx Publishing (Elsevier) in press
1. “Procedeu și compoziție pentru obținerea de noi bionanocompozite polimerice biocompatibile, cu proprietăți antimicrobiene și antioxidante pentru uz medical”, R.N. Darie, R. Lipșa, X. Xxxxxxxxx, X. Xxxxxxx, X. Xxxxxx, X.X. Xxxxxxxx, A/00598/Aug. 2014;
2. Procedeu și compoziție de obținere prin electrofilare/electropulverizare a unor suprafețe poliuretanice bioactive (biocompatibile și antimicrobiene) pentru uz medical și farmaceutic”, B.S. Xxxxxxxx, X. Xxxxxxx (Xxxxxxx), X. Xxxxxxxx, X. Xxxxx, X. Xxxxxx, A/00651/Aug. 2014.
Comunicari:
• Antibacterial membranes based on polyurethane and biological polymers, B.S. Xxxxxxxx, X. Xxxxxxxxxxx, X. Xxxxxxx, R. P. Xxxxxxxx, X.X. Xxxxxx, Xxxxxxxx Xxxxxx, International Conference "Eco-sustainable Food Packaging Based on Polymer Nanomaterials" COST ACTION FA0904, 26-28 February 2014, Roma, Italia.
1. Electrospraying of chitosan/vitamin E mixtures for bioactive coatings, R.P. Dumitriu, B.S. Xxxxxxxx, X. Xxxxxxx, X. Xxxxxx, International Conference on Green Chemistry and Sustainable Engineering Barcelona, 29-31 July 2014
2. Polyurethane/biopolymers films and electrospun fibrous coatings for antimicrobial materials,
R.P. Xxxxxxxx, X. Xxxxxxx, B.S. Xxxxxxxx, X. Xxxxxxxxxxx, X. Xxxxx, X.X. Xxxxxx, X. Xxxxx,
X. Xxxxxx, International Conference on Green Chemistry and Sustainable Engineering Barcelona, 29-31 July 2014
3. Smart textiles obtained by enzymatic activation followed by surface grafting of N- isopropylacrylamide, X. Xxxxxxx, X. Xxxxxxx, X. Xxxxxxxx, X. Xxxxxxxx, X. Xxxxxx, International Conference on Green Chemistry and Sustainable Engineering, 29 - 31 July 2014, Barcelona, Spain;
4. Effect of Poly(ε-caprolactone)/Chitosan ratio on the properties of the Electrospun Nanofibres,
X. Xxxxxxx, R.P. Xxxxxxxx, X. Xxxxxxxxxxxx, X. Xxxxxx, International Conference on Green Chemistry and Sustainable Engineering, 29 - 31 July 2014, Barcelona, Spain.
5. Protein nanolayer with antimicrobial and antioxidant properties immobilized onto cold plasma or gamma activated poly(lactic acid) substrate, E. Xxxxxxx Xxxxxxx, X.X. Xxxxxx, X.X. Xxxxxx,
X. Xxxxxxxxx, X. Xxxxxxx, G. M. Pricope, X. Xxxxxx, 6th Szeged International Workshop on Advances in Nanosciences, 15-18 Octombrie, Szeged, Ungaria;
6. Method and composition for obtaining stratified composites, X. Xxxxxxx, B.S. Xxxxxxxx, X.X. Xxxxxxxx, X. Xxxxxx, The XVIII-th International Exhibition of Inventics, Research and Technological Transfer "INVENTICA 2014" , July 2nd – 4th, 2014, Iasi, Romania;
7. X. Xxxxxxx, X. Xxxxx, X. Xxxxxx, X. Xxxxxx, Xxxx(vinylidene fluoride) surface modified with fibrinogen – Scaffold for cell culture, Joint IUBMB/ICGEB Symposium on Modern Biotechnological Advances for Human Health – BAHH, May 20-22, 2014, Bucharest, Romania;
8. Effect of silver nanoparticles on the dispersion, rheological properties and morphological aspect of solvent cast polyurethane/biopolymers bionanocomposite membranes – R.P. Xxxxxxxx, X. Xxxxxxxxxxx, X. Xxxxx, X. Xxxxxx (P31), Constanta, Romania (6th International Conference "Biomaterials, Tissue Engineering & Medical Devices" BiomMedD’2014, 17-20 Septembrie
2014