Conflict with Attachments. The investigator/institution and the sponsor should sign the protocol, or an alternative contract, to confirm agreement. (ICH E6 4.5.1) The Protocol, including any amendments thereto, constitutes an integral part of this Agreement by reference. In case of any inconsistency between this Agreement and the Protocol, the Protocol shall take precedence on matters of medicine, science and conduct of the Study; otherwise the terms of this Agreement shall prevail.