Common use of Administration of test substance Clause in Contracts

Administration of test substance. T h e t es t s u bs t a n ce o r ve h icle s h o u ld be a d m i n i s t e r ed o r a ll y b y i n t u b a t io n . T h e t es t s u bs t a n ce s h a ll be a d m i n i s t e r ed a t t h e s a m e t i m e e a c h d a y . T h e a n i m a l s s h a ll be weig h ed pe r iodic a ll y a n d t h e dos a ge b a sed o n t h e m os t r ece n t weig h t de t e r m i n a t io n .

Administration of test substance. ( i) Test substance. T h e u se of r a dio a c t ive t es t s u bs t a n ce o r ve h icle s h o u ld be a d m i n i s t e r eq u i r ed o fo r a ll y m a t e- r i a l s b y i a l a n ce a n d m e t a boli t e ide n t u b a ific a- t io n . T r eq u i r e m e n t s of t h e s t u d y . Ide a ll y , t h e p ur i t y of bo t h r a dio a c t ive a n d n o n- r a dio a c t ive t es t s u bs t a n ce s h o u ld be g r e a ll be a d m i n i s t e r ed a t t h e s a m e n 99 pe r ce n t i m e e a c h d a y . T h e r a dio- a c t ive a n i m d n o nr a l dio a c t ive s u bs t a n ces s h a ll be weig c hr o m a t og r a p h ed pe sep a r iodic a ll t el y a n d t h e dos a ge b a sed o n oge t h e m os r t r ece o es t a blis h p ur i t y a n d ide n t weig i t y . If t h e p ur i t de y i s less t h a n 99 pe r ce n t o r if t h e r c hr o m i n a t io og r a m s diffe r s ig n ific a n t l y , E P A s h o u ld be co n s u l t ed.

Administration of test substance. ( i) Test substance. T h e u se of a r a dio a c t ive t es t s u bs t a n ce o r ve h icle s h o u ld be a d m i n i s r eq u i r ed fo r a ll s t u d- ies. Ide a ll y , t h e p ur i t y , r a dio a c t ive a n d n o nr a dio a c t ive, i s g r e a t e r ed o t h a n 99 pe r a ll y b y i - ce n t u b a t io n . T h e r a dio a c t ive a n d n o nr a dio- a c t ive t es t s u bs t a n ce ces s h a ll be a d c hr o m i n i s t e r ed a t t h e s og r a m e t i m e e a c h d a y . T h e a n i m a l s s h a ll be weig p h ed pe sep a r iodic a ll t el y a n d t h e dos a o- ge b a sed o n t h e m os r t r ece o es t a blis h p ur i t y a n d ide n t weig i t y . If t h e p ur i t de y i s less t h a n 99 pe r ce n t o r if t h e r c hr o m i n a t io og r a m s diffe r s ig n ifi- c a n t l y , E P A s h o u ld be co n s u l t ed.