Common use of Administration of test substance Clause in Contracts

Administration of test substance. ( i) Test substance. T h e u se of a r a dio a c t ive t es t s u bs t a n ce i s r eq u i r ed fo r a ll s t u d- ies. Ide a ll y , t h e p ur i t y , r a dio a c t ive a n d n o nr a dio a c t ive, i s g r e a t e r t h a n 99 pe r - ce n t . T h e r a dio a c t ive a n d n o nr a dio- a c t ive t es t s u bs t a n ces s h a ll be c hr o m a t og r a p h ed sep a r a t el y a n d t o- ge t h e r t o es t a blis h p ur i t y a n d ide n t i t y . If t h e p ur i t y i s less t h a n 99 pe r ce n t o r if t h e c hr o m a t og r a m s diffe r s ig n ifi- c a n t l y , E P A s h o u ld be co n s u l t ed.

Administration of test substance. ( i) Test substance. T h e u se of a r a dio a c t ive t es t s u bs t a n ce i s r eq u i r ed fo r a ll m a t e- r i a l s b a l a n ce a n d m e t a boli t e ide n t ific a- t io n r eq u i r e m e n t s of t h e s t u d- iesd y . Ide a ll y , t h e p ur i t y , of bo t h r a dio a c t ive a n d n o n- r a dio a c t ive t es t s u bs t a n ce s h o u ld be g r e a t e r t h a n 99 pe r ce n t . T h e r a dio- a c t ive a n d n o nr a dio a c t ive, i s g r e a t e r t h a n 99 pe r - ce n t . T h e r a dio a c t ive a n d n o nr a dio- a c t ive t es t s u bs t a n ces s h a ll be c hr o m a t og r a p h ed sep a r a t el y a n d t o- ge oge t h e r t o es t a blis h p ur i t y a n d ide n t i t y . If t h e p ur i t y i s less t h a n 99 pe r ce n t o r if t h e c hr o m a t og r a m s diffe r s ig n ifi- c ific a n t l y , E P A s h o u ld be co n s u l t ed.