Amendments to the Research Plans and Research Budgets. During the Research Term, the Parties will jointly develop and submit an update to each applicable Research Plan (including each applicable Research Budget) no later than [***] of each Calendar Year (or more frequently as may be determined by the JSC) and the JSC may modify and will approve each updated Research Plan no later than [***]. HMI will not be required to perform any work that would impose any additional financial obligations beyond those that would not be fully reimbursed by NVS pursuant to Section 3.8 (Research Funding), unless NVS agrees to provide funding for such additional work in writing, and such additional work is included in an amendment approved by the JSC. Following such review and approval by the JSC, each amended Research Plan and Research Budget will become effective immediately and will supersede the applicable previous Research Plan and Research Budget.
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Samples: Collaboration and License Agreement (Homology Medicines, Inc.), Collaboration and License Agreement (Homology Medicines, Inc.), Collaboration and License Agreement (Homology Medicines, Inc.)