Common use of BASIC LEASE PROVISIONS Clause in Contracts

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and Tenant’s Pro Rata Share are both subject to adjustment as provided in this Lease. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 square feet Approximate Rentable Area of Building 95,849 square feet Approximate Tenant’s Pro Rata Share of Building (without the Expansion Premises) 17.60 % 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot of Rentable Area of the Premises, subject to adjustment under this Lease. Initial monthly and annual installments of Basic Annual Rent as of the Rent Commencement Date, subject to adjustment under this Lease: Premises (without the Expansion Premises) Approximately 16,852 square feet $51.00 annually $ 859,452 $ 71,621.00 2.4 Estimated Delivery Date: June 1, 2008 2.5 Term Commencement Date: The later to occur of (i) Substantial Completion (as defined below) of the Core and Shell Work and the Tenant Improvements, or (ii) July 1, 2008 2.6 Term Expiration Date: Five (5) years after the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days after the Term Commencement Date

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 This Lease shall take effect upon the Execution Date date of execution and delivery hereof by all parties hereto and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and Tenant’s Pro Rata Share (as defined below) are both all subject to adjustment as provided in this Lease. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 square feet Approximate Rentable Area of Building 95,849 square feet Approximate Tenant’s Pro Rata Share of Building (without the Expansion Premises) 17.60 %. 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot of Rentable Area of the Premises, subject to adjustment under this Lease. Initial monthly Monthly and annual installments of Basic Annual Base Rent for the Premises, (“Base Rent”) as of the Rent Term Commencement Date, subject to adjustment under this Lease: Premises (without the Expansion Premises) Approximately 16,852 square feet $51.00 annually $ 859,452 $ 71,621.00: 2.4 Estimated Delivery Date: June 1, 2008 2.5 Term Commencement Date: The later to occur of (i) Substantial Completion (as defined below) of the Core and Shell Work and the Tenant Improvements, or (ii) July 1, 2008Execution Date 2.6 2.5 Term Expiration Date: Five Fifteen (515) years after the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days months after the Term Commencement Date 2.6 Option Term: Twelve (12) additional months after the initial Term Expiration Date 2.7 Security Deposit: $21,765.70, subject to increase in accordance with the terms hereof 2.8 Permitted Use: General office and laboratory use and related administrative and ancillary uses as permitted by Applicable Laws (as defined below). 2.9 Address for Rent Payment: XXX-0000 Xxxxxx Xxxx Xxxxxx LLC Unit K X.X. Xxx 00000 Xxx Xxxxxxx, Xxxxxxxxxx 00000-0000 2.10 Address for Notices to Landlord: XXX-0000 Xxxxxx Xxxx Xxxxxx LLC 00000 Xxxxxxxx Xxxxxx Drive San Diego, California 92128 Attn: General Counsel/Real Estate 2.11 Address for Notices to Tenant: 0000 Xxxxxx Xxxx Xxxxxx, Xxxxx 000 Xxx Xxxxx, Xxxxxxxxxx 00000 Attn: Chief Financial Officer 2.12 The following Exhibits are attached hereto and incorporated herein by reference: Exhibit A Premises Exhibit B Services to Be Provided by Landlord Exhibit C [Intentionally omitted] Exhibit D [Intentionally omitted] Exhibit E Form of Letter of Credit Exhibit F Rules and Regulations Exhibit G [Intentionally omitted] Exhibit H Tenant’s Personal Property Exhibit I Form of Estoppel Certificate

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 2.1. This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 2.2 2.2. In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footagefeet. Rentable Area and “Tenant’s Pro Rata Share Share” are both subject to adjustment as provided in this Lease. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 * 28,075 square feet (19,740 square feet of the Premises, as shown on Exhibit A, is sometimes referred to herein as the “Original Premises,” and 8,335 square feet of the Premises, as shown on Exhibit A, is sometimes referred to herein as the “Expansion Space”) Approximate Rentable Area of Building 95,849 330,126 square feet Approximate Tenant’s Pro Rata Share of Building (without Building* 8.50% *Note: Subject to adjustment based upon the Expansion Premises) 17.60 % 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot of Rentable Area of the Premises, subject to adjustment under this LeasePremises as of the Term Commencement Date. 2.3. Initial monthly and annual installments of Basic Annual Base Rent as of for the Rent Commencement DatePremises (“Base Rent”), subject to adjustment under pursuant to Section 4.4 of this Lease: Premises (without With respect to the Expansion Original Premises) Approximately 16,852 square feet $51.00 annually $ 859,452 $ 71,621.00 2.4 Estimated Delivery Date: June 1, 2008 2.5 Term Commencement Date: The later to occur of (i) Substantial Completion (as defined below) of the Core and Shell Work and the Tenant Improvements, or (ii) July 1, 2008 2.6 Term Expiration Date: Five (5) years after the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days after the Term Commencement Date** - the day immediately preceding the first (1st) anniversary of the Term Commencement Date 19,740 $ 29.08 annually $ 47,836.60 $ 574,039.20 With respect to the Expansion Space, the Term Commencement Date*** - the day immediately preceding the first (1st) anniversary of the Term Commencement Date 8,335 $ 29.08 annually $ 20,198.48 $ 242,381.80 * Subject to adjustment based upon the Rentable Area of the Premises as of the Term Commencement Date. ** Subject to abatement until the Rent Commencement Date as provided in Section 7.1 hereof. *** Subject to abatement until the Expansion Space Rent Commencement Date as provided in Section 7.1 hereof.

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 2.1. This Lease shall take effect upon the Execution Date date of execution and delivery hereof by all parties hereto and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto; provided, however, and notwithstanding the provisions of Article 3, Tenant’s repair obligations under Section 19.2 with respect to the Property shall not commence until the earlier of (a) the Term Commencement Date and (b) the date that Tenant occupies the Premises. 2.2 2.2. In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and Tenant’s Pro Rata Share (as defined below) are both all subject to adjustment as provided in this Lease. 2.3. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 square feet Approximate Rentable Area of Building 95,849 square feet Approximate Tenant’s Pro Rata Op Ex Share of Building (without the Expansion Premises) 17.60 %as defined below): 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot of Rentable Area of the Premises, subject to adjustment under this Lease2.4. Initial monthly and annual installments of Basic Annual Base Rent for the Premises (“Base Rent”) as of the Rent Term Commencement Date, subject to adjustment under this Lease: (a) Estimated Term Commencement Date for the Phase 1 Premises: Premises (without the Expansion Premises) Approximately 16,852 square feet $51.00 annually $ 859,452 $ 71,621.00 2.4 Estimated Delivery Date: June 1September 7, 2008 2.5 (b) Estimated Term Commencement Date for the Phase 2 Premises: December 10, 2008 2.6. Estimated Term Expiration Date: September 6, 2013 2.7. Security Deposit: $80,098 2.8. Permitted Use: General office, research and development, engineering, rodent and rodent-sized mammal vivarium, pilot manufacturing and laboratory use, and related uses in conformity with Applicable Laws (as defined below) 2.9. Address for Rent Payment: 34175 Ardenwood Venture, LLC X.X. Xxx 000000 Xxx Xxxxxxx, Xxxxxxxxxx 00000-0000 2.10. Address for Notices to Landlord: 34175 Ardenwood Venture, LLC 00000 Xxxxxxxx Xxxxxx Drive San Diego, California 92128 Attn: General Counsel/Real Estate With a copy to: Xxxxxxx Properties, Inc. 000 Xxxx Xxxxxx Palo Alto, California 94301 2.11. Address for Notices to Tenant: Before the Term Commencement Date: 000 X. Xxxxxxxxxx Blvd. San Jose, California 95128 Attn: Vice President - Finance After the Term Commencement Date: The later to occur Premises Attn: Vice President - Finance 2.12. The following Exhibits are attached hereto and incorporated herein by reference: Xxxxxxx X-0 Xxxxx 0 Premises Exhibit B Work Letter Exhibit C-1 Acknowledgement of (i) Substantial Completion (as defined below) of the Core Phase 1 Term Commencement Date and Shell Work and the Tenant Improvements, or (ii) July 1, 2008 2.6 Term Expiration Date: Five (5) years after the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days after the Date Exhibit C-2 Acknowledgement of Phase 2 Term Commencement DateDate Exhibit D Form of Additional TI Allowance Acceptance Letter Exhibit E Form of Letter of Credit Exhibit F Rules and Regulations Exhibit G-1 Phase l Tenant Improvements Exhibit G-2 Phase 2 Tenant Improvements Exhibit G-3 Landlord Work Exhibit H Signage Exhibit I Tenant’s Personal Property Exhibit J Form of Estoppel Certificate Exhibit K Landlord’s Personal Property

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 This Lease shall take effect upon the Execution Effective Date and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties heretoEffective Date. 2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and Tenant’s Pro Rata Share Shares are both all subject to adjustment as provided in under this Lease, including under Section 9.2. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 square feet Approximate Rentable Area of Building 95,849 square feet Approximate 9,805 Tenant’s Pro Rata Share of Building Project (without the Expansion Premises) 17.60 1.3% 2.3 Initial Annual (and Monthly Rental Installments) of Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot of Rentable Area of the Premises, subject to adjustment under this Lease. Initial monthly and annual installments of Basic Annual Rent (starting as of the Rent Commencement Date, subject to adjustment under this Lease: Premises (without the Expansion Premises) Approximately 16,852 square feet ): Rentable s.f. Per Rentable s.f. Total Annual Total Monthly 9,805 $51.00 28.65 annually $ 859,452 $ 71,621.00$280,913.25 $23,409.44 2.4 Estimated Delivery DateElectric Payment Amount: June 1$2.50 per rsf annually, 2008subject to increase as detailed below 2.5 Base Year: 2006. 2.6 The Term Commencement Date: The Date shall be the date that is the later to occur of (ia) Substantial Completion August 30, 2006, and (b) the date that the Tenant Improvements (as defined below) of the Core and Shell Work and the Tenant Improvementsare Substantially Complete (as defined below), or (ii) July but in no event later than September 29, 2006. The actual Term Commencement Date shall be determined pursuant to Section 4.2. The “Estimated Term Commencement Date” is September 29, 2006. 2.7 Rent Commencement Date: December 1, 20082006. 2.6 2.8 Term Expiration Date: Five (5) years after from the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days after the Term Commencement Date.

BASIC LEASE PROVISIONS. For convenience PREMISES 143,028 rentable square feet in the Building, comprised of the partiesfollowing: (i) 42,073 rentable square feet located on the sixth (6th) floor of the Building (the “6th Floor Premises”), certain basic (ii) 50,475 rentable square feet located on the fifth (5th) floor of the Building (the “5th Floor Premises”) and (iii) 50,480 rentable square feet located on the fourth (4th) floor of the Building (the “4th Floor Premises”). The floor plans depicting the Premises are attached to this Lease as Exhibit A. BUILDING The building commonly known as the One Xxxxxx Street, including all fixtures, equipment and other improvements and appurtenances now located or hereafter erected, located or placed therein or on the land upon which the Building is located. REAL PROPERTY The Building, together with the plot of land upon which it stands. 4th FLOOR PREMISES COMMENCEMENT DATE The date on which Landlord tenders possession of the 4th Floor Premises to Tenant. 4th FLOOR PREMISES SCHEDULED COMMENCEMENT DATE October 1, 2011. 5TH FLOOR PREMISES COMMENCEMENT DATE The date on which Landlord tenders possession of the 5th Floor Premises to Tenant. 5TH FLOOR PREMISES SCHEDULED COMMENCEMENT DATE October 1, 2011. 4th/5th FLOOR PREMISES RENT COMMENCEMENT June 1, 2013, subject to extension by reason of Landlord Delay (defined below) pursuant to the provisions of DATE Section 4.1(b) below. 6th FLOOR PREMISES COMMENCEMENT DATE The date on which Landlord tenders possession of the 6th Floor Premises to Tenant. 6th FLOOR PREMISES SCHEDULED COMMENCEMENT DATE July 1, 2011. 6th FLOOR PREMISES RENT COMMENCEMENT DATE January 2, 2012, subject to extension by reason of Landlord Delay pursuant to the provisions of Section 4.1(b) below. EXPIRATION DATE December 31, 2023, or the last day of any renewal term, if the Term of this Lease are set forth hereinis renewed in accordance with the provisions of Article 28. TERM The provisions set forth herein are subject period of time commencing on the Commencement Date and ending on the Expiration Date. PERMITTED USES General offices and lawful uses ancillary thereto such as data centers, training rooms, kitchenettes, and non-cooking cafeterias. BASE TAX YEAR The Tax Year commencing on July 1, 2011 and ending on June 30, 2012. BASE EXPENSE YEAR Calendar year 2011. TENANT’S PROPORTIONATE SHARE 54.65 %. AGREED AREA OF BUILDING 261,714 rentable square feet, as mutually agreed by Landlord and Tenant. AGREED AREA OF PREMISES 143,028 rentable square feet, as mutually agreed by Landlord and Tenant. FIXED RENT For and with respect to the remaining terms period of time commencing on the 6th Floor Premises Rent Commencement Date through and conditions including December 31, 2012 (both dates inclusive), at the rate of this Lease $1,514,628.00 per annum ($126,219.00 per month), calculated at the rate of $36.00 per rentable square foot, for 42,073 rentable square feet in the Premises (i.e. the 6th Floor Premises). For and are with respect to be interpreted the period of time commencing on January 1, 2013 through and including the day immediately preceding the 4th/5th Floor Premises Rent Commencement Date (both dates inclusive), at the rate of $ 1,556,701.00 per annum ($129,725.08 per month), calculated at the rate of $37.00 per rentable square foot in light the Premises for 42,073 rentable square feet in the Premises (i.e. the 6th Floor Premises). For and with respect to the period of such remaining terms time commencing on the 4th/5th Floor Premises Rent Commencement Date through and conditions. 2.1 This Lease shall take effect upon including December 31, 2013 (both dates inclusive), at the Execution rate of $5,292,036.00 per annum ($441,003.00 per month), calculated at the rate of $37.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2014 through and including December 31, 2014 (both dates inclusive), at the rate of $5,435,064.00 per annum ($452,922.00 per month), calculated at the rate of $38.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2015 through and including December 31, 2015 (both dates inclusive), at the rate of $5,578,092.00 per annum ($464,841.00 per month), calculated at the rate of $39.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2016 through and including December 31, 2016 (both dates inclusive), at the rate of $5,721,120.00 per annum ($476,760.00 per month), calculated at the rate of $40.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2017 through and including December 31, 2017 (both dates inclusive), at the rate of $5,864,148.00 per annum ($488,679.00 per month), calculated at the rate of $41.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2018 through and including December 31, 2018 (both dates inclusive), at the rate of $6,007,176.00 per annum ($500,598.00 per month), calculated at the rate of $42.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2019 through and including December 31, 2019 (both dates inclusive), at the rate of $6,150,204.00 per annum ($512,517.00 per month), calculated at the rate of $43.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2020 through and including December 31, 2020 (both dates inclusive), at the rate of $6,293,232.00 per annum ($524,436.00 per month), calculated at the rate of $44.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2021 through and including December 31, 2021 (both dates inclusive), at the rate of $6,436,260 per annum ($536,355.00 per month), calculated at the rate of $45.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2022 through and including December 31, 2022 (both dates inclusive), at the rate of $6,579,288.00 per annum ($548,274.00 per month), calculated at the rate of $46.00 per rentable square foot in the Premises. For and with respect to the period of time commencing on January 1, 2023 through and including the Expiration Date and(both dates inclusive), except as specifically otherwise provided within at the rate of $6,722,316.00 per annum ($560,193.00 per month), calculated at the rate of $47.00 per rentable square foot in the Premises. ADDITIONAL RENT All sums other than Fixed Rent payable by Tenant to Landlord under this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and including Tenant’s Pro Rata Share are both subject to adjustment as provided in this Lease. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 square feet Approximate Rentable Area of Building 95,849 square feet Approximate Tax Payment, Tenant’s Pro Rata Share Operating Payment, late charges, overtime or excess service charges, damages, and interest and other costs related to Tenant’s failure to perform any of Building (without the Expansion Premises) 17.60 % 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot of Rentable Area of the Premises, subject to adjustment its obligations under this Lease. Initial monthly RENT Fixed Rent and annual installments of Basic Annual Rent as of the Rent Commencement DateAdditional Rent, subject to adjustment under this Lease: Premises (without the Expansion Premises) Approximately 16,852 square feet $51.00 annually $ 859,452 $ 71,621.00 2.4 Estimated Delivery Date: June 1, 2008 2.5 Term Commencement Date: collectively. INTEREST RATE The later to occur lesser of (i) Substantial Completion (as defined below) of 3% per annum above the Core then-current Base Rate, and Shell Work and the Tenant Improvements, or (ii) July 1the maximum rate permitted by applicable Requirements. TENANT’S ADDRESSES FOR NOTICES 000 Xxxx Xxxxxx Xxxxxxxxx, 2008 2.6 Term Expiration DateXX 00000 COPIES TO WilmerHale LLP 00 Xxxxx Xxxxxx Xxxxxx, XX 00000 Attn: Five Xxxx Xxxxxxxxxx, Esq. LANDLORD’S ADDRESS FOR NOTICES c/o Principal Real Estate Investors 000 Xxxxx Xxxxxx Xxx Xxxxxx, XX 00000-0000 Attn: Asset Management East States Region Copies to: Goulston & Storrs, P.C. 000 Xxxxxxxx Xxxxxx Xxxxxx, Xxxxxxxxxxxxx 00000 Attn: Xxxxx X. Xxxxxx, Esq. TENANT’S BROKER T3 Advisors. LANDLORD’S BROKER Xxxxx Lang LaSalle. LANDLORD’S ALLOWANCE $7,151,400.00. LANDLORD’S BATHROOM UPGRADE ALLOWANCE $200,000.00. ONE XXXXXXX PARK LEASE That certain lease agreement, dated as of the date of this Lease, between Xxxxxxx Park One, LLC, as landlord, and Tenant, as tenant, pursuant to which Tenant has leased premises consisting of 19,826 rentable square feet in the building adjacent to the Building commonly known as One Xxxxxxx Park (5) years after the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: “One hundred eighty (180) days after the Term Commencement DateXxxxxxx Park”)

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 2.1. This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 2.2 2.2. In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and Tenant’s Pro Rata Share (as defined below) are both subject to adjustment as provided in this Lease. 2.3. Approximate Rentable Area Initial monthly and annual installments of Premises (without the Expansion Premises) 16,852 square feet Approximate Rentable Area of Building 95,849 square feet Approximate Tenant’s Pro Rata Share of Building (without the Expansion Premises) 17.60 % 2.3 Basic Annual Base Rent for the Premises (“Basic Annual Base Rent”) as of the Term Commencement Date, shall be $51.00 per square foot of Rentable Area of as set forth in Exhibit D attached hereto (the Premises“Base Rent Schedule”), subject to adjustment under this Lease: 2.4. Initial monthly and annual installments of Basic Annual Rent as of the Rent Commencement Date, subject to adjustment under this Lease: Premises (without the Expansion Premises) Approximately 16,852 square feet $51.00 annually $ 859,452 $ 71,621.00 2.4 Estimated Delivery Date: June 1, 2008 2.5 Term Commencement Date: The later to occur July 1, 2010 2.5. Estimated Term Expiration Date: May 31, 2017 2.6. Security Deposit: $125,000.00 2.7. Permitted Use: Office and laboratory use in conformity with all federal, state, municipal and local laws, codes, ordinances, rules and regulations of (i) Substantial Completion Governmental Authorities (as defined below) of the Core and Shell Work and the Tenant Improvements), committees, associations, or other regulatory committees, agencies or governing bodies having jurisdiction over the Premises, the Building, the Property, the Project, Landlord or Tenant, including both statutory and common law and hazardous waste rules and regulations (ii) July 1“Applicable Laws”) 2.8. Address for Rent Payment: BMR - Xxxx Xxxxxxx Court XX Xxx 000000 Xxx Xxxxxxx, 2008XX 00000-0000 2.6 2.9. Address for Notices to Landlord: BMR-Xxxx Xxxxxxx Court LLC 00000 Xxxxxxxx Xxxxxx Drive San Diego, California 92128 Attn: Vice President, Real Estate Counsel 2.10. Address for Notices to Tenant: Prior to Term Expiration Date: Five (5) years after the Rent Commencement Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days after the Regulus Therapeutics Inc. 0000 Xxxxxxxxxx Xxxx Carlsbad, California 92008 Attn: Xxxxx Xxxxxx, Executive Vice President After Term Commencement Date: Regulus Therapeutics Inc. 0000 Xxxx Xxxxxxx Court San Diego, California 92121 Attn: Xxxxx Xxxxxx, Executive Vice President 2.11. The following Exhibits are attached hereto and incorporated herein by reference: Exhibit A Premises Exhibit A-l Suite 210 Depiction Exhibit B Work Letter Exhibit C Acknowledgement of Term Commencement Date and Term Expiration Date Exhibit D Base Rent Schedule Exhibit E Rules and Regulations Exhibit F Tenant’s Personal Property Exhibit G Form of Estoppel Certificate Exhibit H Signage Exhibit I FF&E

BASIC LEASE PROVISIONS. For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 2.1 This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footagefeet. Rentable Area and “Tenant’s Pro Rata Share Share” are both subject to adjustment as provided in this Lease. Approximate Rentable Area of Premises (without the Expansion Premises) 16,852 6,581 square feet Approximate Rentable Area of Building 95,849 (1,380 square feet Approximate Tenant’s Pro Rata Share of Building (without the Expansion Premises) 17.60 %, as shown on Exhibit A, is sometimes referred to herein as “Premises A,” and 5,201 square feet of the Premises, as shown on Exhibit A, is sometimes referred to herein as the “Premises B”) 2.3 Basic Annual Initial monthly and annual installments of Base Rent for the Premises (“Basic Annual Base Rent”) shall be $51.00 per square foot of Rentable Area of the Premises), subject to adjustment under this Lease. Initial monthly and annual installments pursuant to Section 4.6 of Basic Annual Rent as of the Rent Commencement Date, subject to adjustment under this Lease: With respect to Premises A, the period commencing on the Term Commencement Date and ending on the day immediately preceding the first (without 1st) anniversary of the Expansion Premises) Approximately 16,852 square feet Delivery Date 1,380 $51.00 34.00 annually $ 859,452 $ 71,621.00$3,910.00 $46,920.00 2.4 Estimated Delivery Date: June 1, 2008 2.5 Term Commencement Date: The later to occur of date that is sixteen (i16) Substantial Completion (as defined below) of the Core and Shell Work and the Tenant Improvements, or (ii) July 1, 2008 2.6 Term Expiration Date: Five (5) years weeks after the Rent Commencement Execution Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 2.7 Rent Commencement Date: One hundred eighty (180) days after the Term Commencement Date.