Cannabinoid biosynthesis Sample Clauses

Cannabinoid biosynthesis. Histochemical (Xxxxx and Xxxxxxxxxx, 1976; Xxxxx et al., 1988), immunochemical (Xxx and Xxxxxxxx, 1997) and chemical (Xxxxxx et al., 1981) studies have confirmed that glandular hairs are the main site of cannabinoid production, although they have also been detected in stem, pollen, seeds and roots by immunoassays (Xxxxxx and Xxxxxxx, 1999) and chemical analysis (Xxxxxx, 2004; Xxxx et al., 2000). The precursors of cannabinoids are synthesized from 2 pathways, the polyketide pathway (Xxxxxxx et al., 1975) and the deoxyxylulose phosphate/methyl-erythritol phosphate (DOXP/MEP) pathway (Xxxxxxxxxxx et al., 2001) (Figure 3). From the polyketide pathway, olivetolic acid is derived and from the DOXP/MEP pathway, geranyl diphosphate (GPP) is derived. Both are condensed by the prenylase geranyl diphosphate:olivetolate geranyltransferase (GOT) (Fellermeier and Xxxx, 1998) to form cannabigerolic acid (CBGA), which is a common substrate for three oxydocyclases: Cannabidiolic acid synthase (Xxxxx et al., 1996), Δ9-Tetrahydrocannabinolic acid synthase (Xxxxx et al., 1995a) and Cannabichromenic acid synthase (Xxxxxxxx et al., 1998), forming cannabidiolic acid (CBDA), Δ9-tetrahydrocannabinolic acid (Δ9-THCA) and cannabichromenic acid (CBCA), respectively (Xxxxxxxx et al., 1999).
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Related to Cannabinoid biosynthesis

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