Miscellaneous cannabinoids Sample Clauses

Miscellaneous cannabinoids. The psychotropic activities of cannabinoids are well known (Xxxxx and Xxxxxxx, 1973; Xxxxxxxxxxx and X’Xxxxx, 2006); however, in clinical studies, in vitro and in vivo, some other pharmacological effects of cannabinoids are observed such as antinociceptive, antiepileptic, cardiovascular, immunosuppressive (Ameri, 1999), antiemetic, appetite stimulation (Mechoulam and Xxx Xxxxxx, 1999), antineoplastic (Xxxxxxxx et al., 1976; Xxxxx et al., 2004), antimicrobial (ElSohly et al., 1982), anti-inflammatory (Xxxxxxxxx et al., 1988), neuroprotective antioxidants (Xxxxxxx et al., 1988) and positive effects in psychiatric syndromes, such as depression, anxiety and sleep disorders (Grotenhermen, 2002; Musty, 2004). These effects could be due to agonistic nature of these compounds with respect to the cannabinoid CB1- and CB2 receptors (Xxxxxxx et al., 1990; Xxxxx et al., 1993) which compete with endocannabinoids (Xxxxxxxxx et al., 1998), a family of cannabinoid receptor ligands participating in modulation of neurohumoral activity (Xx Xxxxx et al., 2007; Xxxxxxxxx et al., 1999; Xxxxxxx et al., 2005). Some therapeutic applications from cannabis, cannabinoids, cannabinoid analogs and CB receptor agonist/antagonist are shown in table 1. Table 1. Some pharmacological applications of medicinal cannabis, THC, analogs and others. Product Components/ active ingredient Prescription/ clinical effects Administering Country Reference/ Company Cannabis flos variety Bedrocan® Cannabis flos Dry flowers, 18% Δ9-THC and 0.2% CBD Spasticity with pain in MS or spinal cord injury; nausea and vomiting by radiotherapy, chemotherapy and HIV-medication; chronic neuralgic pain and Gilles de la Tourette Syndrome; palliative treatment of cancer and HIV/AIDS Spasticity with pain in MS or spinal cord injury; Smoking NL Office of Medicinal Cannabis (OMC) Smoking NL Office of Medicinal variety Bedrobinol® Dry flowers, 13% Δ9-THC and
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