Challenges of gene delivery Sample Clauses

Challenges of gene delivery. Gene delivery is a multi-step process in which a number of barriers must be overcome including internalisation and intracellular barriers such as cell entry, endosomal escape and nuclear entry (Xxxxxxx, M. et al., 2008, Xxxxxxx, X. and X. Xxxxxxxx, 2006). siRNA has an advantage over pDNA in that it does not require nuclear localization for its action as it acts in the cytoplasm. The challenges of cationic lipid-mediated pDNA/siRNA delivery are considered below.
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