Common use of Designation of Research Programs and Development Projects Clause in Contracts

Designation of Research Programs and Development Projects. Regulus’ officers will be responsible for reviewing the results of Research and Development activities under the Operating Plan and designating (subject to the approval of the Managing Board) from time to time Research Programs and Development Projects. A “Research Program” will begin upon the commencement of discovery or characterization activities focused on one or more specific xxXXX(s) after preliminary validation of the biological function of such xxXXX(s) has been identified (i.e., compound discovery, not target validation) and will include all activities with respect to the Development, Manufacturing and Commercialization of xxXXX Compounds and xxXXX Therapeutics directed to such xxXXX(s). A Research Program will become a “Development Project” (and thereafter will no longer be a Research Program) when Regulus’ officers recommend, and the Managing Board agrees, that a sufficient portfolio of data exists to support the initiation of a [***] on a xxXXX Compound drug candidate targeting such xxXXX(s). Regulus will maintain a written list of the then-current Research Programs and Development Projects (each, a “Program/Project List”).

Designation of Research Programs and Development Projects. Regulus’ officers will be responsible for reviewing the results of Research and Development activities under the Operating Plan and designating (subject to the approval of the Managing Board) from time to time Research Programs and Development Projects. A “Research Program” will begin upon the commencement of discovery or characterization activities focused on one or more specific xxXXX(s) after preliminary validation of the biological function of such xxXXX(s) has been identified (i.e., compound discovery, not target validation) and will include all activities with respect to the Development, Manufacturing and Commercialization of xxXXX Compounds and ***Confidential Treatment Requested xxXXX Therapeutics directed to such xxXXX(s). A Research Program will become a “Development Project” (and thereafter will no longer be a Research Program) when Regulus’ officers recommend, and the Managing Board agrees, that a sufficient portfolio of data exists to support the initiation of a [...***...] on a xxXXX Compound drug candidate targeting such xxXXX(s). Regulus will maintain a written list of the then-current Research Programs and Development Projects (each, a “Program/Project List”).

Designation of Research Programs and Development Projects. Regulus’ officers will be responsible for reviewing the results of Research and Development activities under the Operating Plan and designating (subject to the approval of the Managing Board) from time to time Research Programs and Development Projects. A “Research Program” will begin upon the commencement of discovery or characterization activities focused on one or more specific xxXXX(smxXXX(s) after preliminary validation of the biological function of such xxXXX(smxXXX(s) has been identified (i.e., compound discovery, not target validation) and will include all activities with respect to the Development, Manufacturing and Commercialization of xxXXX mxXXX Compounds and xxXXX mxXXX Therapeutics directed to such xxXXX(smxXXX(s). A Research Program will become a “Development Project” (and thereafter will no longer be a Research Program) when Regulus’ officers recommend, and the Managing Board agrees, that a sufficient portfolio of data exists to support the initiation of a [***] on a xxXXX mxXXX Compound drug candidate targeting such xxXXX(smxXXX(s). Regulus will maintain a written list of the then-current Research Programs and Development Projects (each, a “Program/Project List”).

Designation of Research Programs and Development Projects. Regulus’ officers will be responsible for reviewing the results of Research and Development activities under the Operating Plan and designating (subject to the approval of the Managing Board) from time to time Research Programs and Development Projects. A “Research Program” will begin upon the commencement of discovery or characterization activities focused on one or more specific xxXXX(smxXXX(s) after preliminary validation of the biological function of such xxXXX(smxXXX(s) has been identified (i.e., compound discovery, not target validation) and will include all activities with respect to the Development, Manufacturing and Commercialization of xxXXX mxXXX Compounds and xxXXX mxXXX Therapeutics directed to such xxXXX(smxXXX(s). A Research Program will become a “Development Project” (and thereafter will no longer be a Research Program) when Regulus’ officers recommend, and the Managing Board agrees, that a sufficient portfolio of data exists to support the initiation of a [***] on a xxXXX mxXXX Compound drug candidate targeting such xxXXX(smxXXX(s). Regulus will maintain a written list of the then-current Research Programs and Development Projects (each, a “Program/Project List”).