Common use of Gene Therapy Clause in Contracts

Gene Therapy. Students will learn the history of gene therapy and the principal concepts behind gene therapy applications. We will cover the early gene therapy failures and the important lessons learned from these studies, which led to modified strategies based upon improved understanding of genetic components and how this knowledge led to successful translation for the treatment of human diseases like genetic disorders and cancer. Genome Editing: Students will be introduced to genome editing technologies, including transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFNs) and clustered regularly interspaced short palindromic repeats (CRISPR)-associated nuclease Cas9. Bioinformatics: Students will get an overview of bioinformatics resources for analysis of protein sequences. They will be introduced to immunomic and infectivity databases and learn how to deal with immunogenicity analysis. ECTS Lectures Seminars Practical work Digital learning Personal work 5 32 hours 32 hours 86 hours Assessment method 50 % Oral presentation 50 % Review of a research paper. Emerging Viral Infections: Discovery and Intervention Strategies Organization: Hannover Medical School Teaching unit coordinator: Teaching unit coordinator: Xxxxxx XXXXXXXXX, Xxxx XXXXXXXXXXX Position: Professor, Research Center for Emerging Infections and Zoonoses (RIZ) Teaching unit outline This module will address fundamental aspects of viral zoonotic pathogens, such as discovery of novel viruses and assessment of their zoonotic potential, genetic analysis and phylogeny, host restriction factors and virus adaptation to novel host species, pathogenesis, intervention strategies and the use of a molecular toolbox to investigate viral determinants of virulence and transmissibility. Some important well characterized viral pathogens will be discussed in depth to illuminate different prophylactic and therapeutic intervention strategies. Topics addressed

Gene Therapy. Students will learn the history of gene therapy and the principal concepts behind gene therapy applications. We will cover the early gene therapy failures and the important lessons learned from these studies, which led to modified strategies based upon improved understanding of genetic components and how this knowledge led to successful translation for the treatment of human diseases like genetic disorders and cancer. Genome Editing: Students will be introduced to genome editing technologies, including transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFNs) and clustered regularly interspaced short palindromic repeats (CRISPR)-associated nuclease Cas9. Bioinformatics: Students will get an overview of bioinformatics resources for analysis of protein sequences. They will be introduced to immunomic and infectivity databases and learn how to deal with immunogenicity analysis. ECTS Lectures Seminars Practical work Digital learning Personal work 5 32 18 hours 32 3 30 hours 86 hours 89hours Assessment method 50 100 % Oral presentation 50 % Ungraded course work: Review of a research paper. Emerging Viral Infections: Discovery and Intervention Strategies Organization: University of Veterinary Medicine Hannover Medical School Teaching unit coordinator: Teaching unit coordinator: Xxxxxx XXXXXXXXX, Xxxx XXXXXXXXXXX Position: Professor, Research Center for Emerging Infections and Zoonoses (RIZ) Teaching unit outline This module will address fundamental aspects of viral zoonotic pathogens, such as discovery of novel viruses and assessment of their zoonotic potential, genetic analysis and phylogeny, host restriction factors and virus adaptation to novel host species, pathogenesis, intervention strategies and the use of a molecular toolbox to investigate viral determinants of virulence and transmissibility. Some important well characterized viral pathogens will be discussed in depth to illuminate different prophylactic and therapeutic intervention strategies. Topics addressed