neurocircuitry Sample Clauses

neurocircuitry. When integrating the evidence described in the previous paragraphs, the neurocir- cuitry that mediates reward and translates biologically relevant stimuli into adaptive behavioural responses, also termed the ‘motive circuit’ can be envisaged as consisting of a network of several brain regions that communicate via multiple neurotransmit- ters. Similarly, neuroimaging studies in humans have indicated that cocaine craving is associated with the activation of several brain regions, including the PFC, amygdala, hippocampus and the striatal complex 106,229,353. A simplified representation of the motive circuit is shown in figure 4 (for a review see: 328). In line with the classical ‘dopamine hypothesis’ of addiction, the mesocorticolimbic dopaminergic projection from the VTA to the NAc, PFC and amygdala forms the core of the motive circuit. The PFC (prelimbic, anterior cingulate and ventral orbital Xxx NAc shell NAc core VTA PFCv PFCd SNc SNr CP Dopamine Glutamate
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