Common use of PARTIES AND DATE Clause in Contracts

PARTIES AND DATE. This Fifth Amendment to Lease (the “Amendment”) dated May 18, 2006, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation (“Landlord”), and ALSIUS CORPORATION, a California corporation (“Tenant”).

PARTIES AND DATE. This Fifth Amendment to Lease (the “Amendment”) dated May 18November 21, 20062013, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation company (“Landlord”), and ALSIUS CORPORATIONSPECTRUM PHARMACEUTICALS, INC., a California Delaware corporation (“Tenant”).

PARTIES AND DATE. This Fifth Sixth Amendment to Lease (the “Amendment”) dated May 18January 31, 20062014, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation (“Landlord”), and ALSIUS CORPORATIONSPECTRUM PHARMACEUTICALS, INC., a California Delaware corporation (“Tenant”).

PARTIES AND DATE. This Fifth Sixth Amendment to Lease (the “Amendment”) dated May 18, 2006and effective as of August 2nd 2011, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation company (“Landlord”), and ALSIUS BROADCOM CORPORATION, a California corporation (“Tenant”).

PARTIES AND DATE. This Fifth Amendment to Lease (the “"Amendment”") dated May 18as of February 26, 20062013, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation company (“"Landlord”"), and ALSIUS BROADCOM CORPORATION, a California corporation (“"Tenant”").

PARTIES AND DATE. This Fifth Amendment to Lease (the “Amendment”) dated May 18and effective as of April 24, 20062011, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation company (“Landlord”), and ALSIUS BROADCOM CORPORATION, a California corporation (“Tenant”).