Radial artery diameter measurements Sample Clauses

Radial artery diameter measurements. Simultaneous assessment of radial artery diameter and FBF during brachial artery infusion of vasoactive substances provides a powerful tool to probe the differential vasoregulatory pathways of muscular conduit arteries and resistance arterioles. High resolution vascular ultrasound measurements of the radial artery diameter were obtained during steady state conditions within a few minutes of FBF measurements. In order to avoid a possible influence of a reactive hyperaemic response following deflation of wrist cuff, radial artery diameter measurements were performed before each set of FBF measurements. A 10MHz ultrasound probe (Aspen, Siemens, Germany) was placed 3 to 5cm distal to the point of arterial cannulation to image the right radial artery. Once a good quality two dimensional radial artery image was acquired, the ultrasound probe was placed in a stereotactic holder with micrometer adjustment to allow precise optimisation of image quality throughout the study. End-diastolic (ECG referenced) radial artery diameter (RAD) was obtained from images acquired every 3 seconds over 2 minutes at baseline and when steady state had been achieved during drug infusion. Images were analysed off-line using automated software (Brachial analyser, Medical Imaging Applications, USA) which provided a mean diameter over a length of artery of approximately 10mm. The coefficient of variation of arterial diameter measurements repeated at baseline and during drug infusion was 4%. The change in radial artery diameter was reported as percentage change relative to baseline.
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